Evidence map›Paper›PMID 42567755›Full record

ArticleDiagnostic and interventional imaging2026

Association between radial meniscal tears with and without posterior root involvement and subchondral insufficiency fracture of the knee on MRI: The mediating role of meniscal extrusion.

Mohamad Z Alzaher, Wasim Issa, Ambrose J Huang, Jad S Husseini, William E Palmer, Jamie Collins, S Reza Jafarzadeh, Soheil Mohammadi, Theresa S Patzer, Samir Ghandour and 4 more

Abstract read
In one paragraph

Article in Diagnostic and interventional imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Mohamad Z AlzaherDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Wasim IssaDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Ambrose J HuangDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Jad S HusseiniDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
William E PalmerDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Jamie CollinsOrthopaedic and Arthritis Center for Outcomes Research (OrACORe), Department of Orthopaedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
S Reza JafarzadehDepartment of Emergency Medicine, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA; Section of Rheumatology, Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02115, USA.
Soheil MohammadiMallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Theresa S PatzerDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Samir GhandourDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Tuhina NeogiSection of Rheumatology, Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02115, USA.
Jeffrey N KatzOrthopaedic and Arthritis Center for Outcomes Research (OrACORe), Department of Orthopaedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Ali GuermaziQuantitative Imaging Center, Department of Radiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02115, USA.
Mohamed JarrayaDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Electronic address: mjarraya@mgh.harvard.edu.

Funding

Research and Evaluation Support Core Unit (RESCU Core)P30AR072571 · NIAMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Michael Paul Lavalley · 2019 to 2026
$6.9M
The Role of Urate in Knee Osteoarthritis-Related Inflammation, Pathology and PainK24AR070892 · NIAMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI TUHINA NEOGI · 2017 to 2026
$1.1M
Unraveling the discordance between structural damage and pain phenotypes in knee osteoarthritisK23AR084603 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI Mohamed Jarraya · 2024 to 2026
$525k
Bayesian approaches to identify persons with osteoarthritis in electronic health records and administrative health data in the absence of a perfect reference standardR21AR081442 · NIAMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI JAFARZADEH, S. REZA · 2023 to 2023
$254k
NIAMS NIH HHS K23 AR084603NIAMS NIH HHS K24 AR070892NIAMS NIH HHS P30 AR072571NIAMS NIH HHS R21 AR081442
6 · The paper itself

Abstract

purposeThe purpose of this study was to evaluate the relationship between subchondral insufficiency fracture (SIF) of the knee and radial meniscal tears on magnetic resonance imaging (MRI) and to examine within the medial compartment the potential mediating role of meniscal extrusion in this relationship. MATERIALS AND

methodsA retrospective matched case-control study of knee MRI examinations obtained from November 2021 to November 2024 was performed. MRIs were reviewed for SIF, meniscal tear morphology, and meniscal extrusion grade. Associations between radial tears and SIF (overall and medial compartment) were evaluated using conditional logistic regression adjusted for age, sex, and body mass index. Medial-compartment mediation was examined using a natural effects model with medial meniscal extrusion as the mediator.

resultsThe cohort included 343 patients with SIF (65.4 ± 10.1 [standard deviation] years; 226 women) and 343 patients without SIF (66.4 ± 10.0 [standard deviation] years; 224 women). Compared with knees without radial tears, odds of SIF were higher in the presence of radial root tears (odds ratio [OR], 7.62; 95% confidence interval [CI]: 4.40-13.21) and radial non-root tears (OR, 5.26; 95% CI: 2.48-11.15), with similar findings in the medial compartment. In mediation analysis, medial radial root tears showed an indirect association with medial SIF through medial meniscal extrusion (OR, 1.46; 95% CI: 1.16-1.84), accounting for 16.6% of the total effect.

conclusionRadial root and non-root tears are strongly associated with SIF on MRI, particularly in the medial compartment. Meniscal extrusion explained a small proportion of this association, suggesting that additional biomechanical pathways are likely in play.

Indexed as

KneeMagnetic resonance imagingMeniscal extrusionMeniscal tearSubchondral insufficiency fracture

Identifiers

PMID42567755
PMCPMC13488938

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.