Evidence map›Paper›PMID 42567517›Full record

ArticleThe Journal of biological chemistry2026

Hearing loss associated with CDC42 in mice and humans (Takenouchi-Kosaki syndrome): CDC42 and RHOQ synergistically function in cochlear hair cells.

Takehiko Ueyama, Akira Ganaha, Shunkou Kurasawa, Hiroaki Mohri, Takashi Nakamura, Shigefumi Morioka, Fumiya Kawama, Shota Kitayama, Naoki Oishi, Tadashi Kaname and 4 more

Abstract read
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In one paragraph

Article in The Journal of biological chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Takehiko UeyamaLaboratory of Molecular Pharmacology, Biosignal Research Center, Kobe University, Kobe, Japan. Electronic address: tueyama@kobe-u.ac.jp.
Akira GanahaDepartment of Otolaryngology-Head and Neck Surgery, International University of Health and Welfare Narita Hospital, Narita, Japan; Department of Otorhinolaryngology-Head and Neck Surgery, University of the Ryukyus, Inowan, Japan.
Shunkou KurasawaLaboratory of Molecular Pharmacology, Biosignal Research Center, Kobe University, Kobe, Japan.
Hiroaki MohriLaboratory of Molecular Pharmacology, Biosignal Research Center, Kobe University, Kobe, Japan.
Takashi NakamuraLaboratory of Molecular Pharmacology, Biosignal Research Center, Kobe University, Kobe, Japan.
Shigefumi MoriokaLaboratory of Molecular Pharmacology, Biosignal Research Center, Kobe University, Kobe, Japan.
Fumiya KawamaLaboratory of Molecular Pharmacology, Biosignal Research Center, Kobe University, Kobe, Japan.
Shota KitayamaLaboratory of Molecular Pharmacology, Biosignal Research Center, Kobe University, Kobe, Japan.
Naoki OishiDepartment of Otorhinolaryngology, Head and Neck Surgery, Keio University School of Medicine, Tokyo, Japan.
Tadashi KanameDepartment of Genome Medicine, National Center for Child Health and Development, Tokyo, Japan.
Keiji TabuchiDepartment of Otolaryngology-Head and Neck Surgery, University of Tsukuba, Tsukuba, Japan.
Kenjiro KosakiCenter for Medical Genetics, Keio University School of Medicine, Tokyo, Japan.
Toshiki TakenouchiDepartment of Pediatric Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Hirofumi SakaguchiLaboratory of Molecular Pharmacology, Biosignal Research Center, Kobe University, Kobe, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CDC42 is involved in multiple signaling pathways, including actin organization and polarity. We previously reported progressive sensorineural hearing loss (SNHL) in inner ear hair cell (HC)-specific Cdc42-knockout (Atoh1-Cre

Indexed as

actinapical junctional complexCDC42cochlear hair cellcofilinRho-family small GTPaseRHOQsensorineural hearing lossstereociliaTakenouchi–Kosaki syndrometight junction

Identifiers

PMID42567517
PMCPMC13559824

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.