ArticleAnnals of medicine2026
A multimodal bronchoscopic approach for diagnosing peripheral ground-glass nodules using Cone-Beam computed tomography and cryobiopsy: a preliminary study.
Article in Annals of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
backgroundGround-glass nodules (GGNs) remain challenging to diagnose using endobronchial ultrasound-guided transbronchial biopsy (EBUS-TBB) due to limited visibility and low tissue yield. We evaluated a multimodal bronchoscopic approach and investigated a radiographic predictor of EBUS invisibility to guide the use of cone-beam computed tomography (CBCT).
methodsIn this single-center retrospective study, patients with GGNs (consolidation-to-tumor ratio <50%) who underwent EBUS-TBB followed by transbronchial cryobiopsy (TBC) using ultrathin bronchoscopy with intraprocedural CBCT between January 2022 and December 2024 were included. The primary endpoint was diagnostic accuracy.
resultsNinety patients were included. Diagnostic accuracy was 68.9% for EBUS-TBB with CBCT and 76.7% for TBC (
conclusionA multimodal bronchoscopic approach provides favorable diagnostic yield for GGNs, and the combined use of forceps biopsy and TBC improves diagnostic performance and tissue acquisition. Lower HU values predict EBUS invisibility and may help guide the selective use of CBCT.
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