Evidence map›Paper›PMID 42566821›Full record

ArticleThe journal of prevention of Alzheimer's disease2026

Cost-effectiveness of the special care unit for persons with dementia.

Ron Handels, Bernhard Michalowsky, Aline Mendes, Sverre Bergh, Bruno Mario Cesana, Alfonso Ciccone, Emmanuel Cognat, Andrea Fabbo, Sara Fascendini, Giovanni B Frisoni and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of prevention of Alzheimer's disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Ron HandelsFaculty of Health Medicine and Life Sciences, Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Dr. Tanslaan 12, P.O. box 6161, 6200 MD, Maastricht, the Netherlands; Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Karolinska Vägen 22, 171 64, Solna, Sweden. Electronic address: ron.handels@maastrichtuniversity.nl.
Bernhard MichalowskyGerman Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Ellernholzstrasse 1-2, 17487, Greifswald, Germany.
Aline MendesDepartment of Readaptation and Geriatrics, University Hospitals and University of Geneva, 24 rue du Général-Dufour 1211, Geneva, Switzerland.
Sverre BerghResearch centre for Age-Related Functional Decline and Disease, Innlandet Hospital Trust, P.O. box 68, 2313, Ottestad, Norway.
Bruno Mario CesanaDepartment of Clinical Sciences and Community Health, Unit of Medical Statistics, Biometry and Bioinformatics "Giulio A. Maccacaro" Faculty of Medicine and Surgery, University of Milan, Via Festa del Perdono 7, 20122, Milan, Italy.
Alfonso CicconeMemory clinic, Department of Neurology, ASST di Mantova, Mantua, Italy; Memory Clinic, Department of Neurology, ASST di Mantova, Mantova, Italy.
Emmanuel CognatUniversité Paris Cité, 101 rue de Tolbiac, UMRS 1144, INSERM, Paris, France; Cognitive Neurology Center, AP-HP.Nord, Site Lariboisière Fernand-Widal, 200 Rue du Faubourg Saint-Denis, 75010, Paris, France.
Andrea FabboCognitive Disorders and Dementia Unit, Health Authority and Services (AUSL) of Modena, Strada Minutara Hangar 3, 41122, Modena, Italy.
Sara FascendiniFERB Alzheimer Centre, Ospedale Briolini, via A. Manzoni, 130, 24025, Gazzaniga, Italy.
Giovanni B FrisoniMemory Centre, Department of Readaptation and Geriatrics, University Hospitals and University of Geneva, 24 rue du Général-Dufour 1211, Geneva, Switzerland.
Lutz FroelichDepartment of Geriatric Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, J 5 68159, Mannheim, Germany.
Patrizia MecocciDivision of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Piazza Università, 1 06123, Perugia Italy; NVS Department, Karolinska Institutet, Karolinska Vägen 22, 171 77, Stockholm, Sweden.
Paola MerloDept. of Neurology, Humanitas Gavazzeni, Via Mauro Gavazzeni, 21, 24125, Bergamo Italy.
Oliver PetersCharité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Department of Psychiatry, Charitéplatz 1, 10117, Berlin, Germany.
Magdalini Tsolaki1st Department of Neurology, Medical School, Faculty of Health Sciences, Aristotle University of Thessaloniki, Alzheimer Hellas, and Laboratory of Neurodegenerative Diseases, Center for Interdisciplinary Research and Innovation (CIRI - AUTh), Aristotle University of Thessaloniki, 54124, Thessaloniki, Hellas, Greece.
Carlo Alberto DefantiCognitive Neurology Center, AP-HP.Nord, Site Lariboisière Fernand-Widal, 200 Rue du Faubourg Saint-Denis, 75010, Paris, France.
RECage consortium collaborators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionWe aimed to estimate the cost-effectiveness of the patient-centered special care unit for behavioral and psychological symptoms of dementia (SCU-B) in the Respectful Caring for the Agitated Elderly (RECage) study.

methodsA health-economic evaluation was performed alongside a controlled European multicenter three-year longitudinal cohort study enrolling 508 participants in a non-SCU-B cohort and SCU-B cohort. Health service resource use, costs, quality-adjusted life years (QALYs), and incremental cost per QALY gained were assessed.

resultsTotal QALYs were lower (-0.13; bootstrap-interval -0.23 to -0.02) and total costs were higher (€24,960; bootstrap-interval 14,870 to 35,090) in the SCU-B cohort. Base case and sensitivity analyses indicated the SCU-B was likely not cost-effective. DISCUSSION: Widespread implementation as well as disinvestment of SCU-B cannot be recommended, given the uncertainty of the study results. We recommend a randomized study stratified by (local/county) region for conclusive evidence.

Indexed as

Behavioral and psychological symptomsCost-effectivenessDementiaHealth-economic evaluationSpecial care unit

Identifiers

PMID42566821
PMCPMC13476509

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.