Evidence map›Paper›PMID 42566817›Full record

ArticleDNA repair2026

Sex and base excision repair as key susceptibility factors for alkylation-induced mutations, toxicity and hepatic cancer.

Jennifer E Kay, Joshua J Corrigan, Lindsay B Volk, Amanda L Armijo, Norah A Owiti, Lee J Pribyl, Ilana S Nazari, Dorothea K Torous, Svetlana L Avlasevich, Robert G Croy and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in DNA repair, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Jennifer E KayDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Silent Spring Institute, Newton, MA 02460, USA; Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA 01239, USA. Electronic address: kay@silentspring.org.
Joshua J CorriganDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA 01239, USA.
Lindsay B VolkDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA 01239, USA.
Amanda L ArmijoDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA 01239, USA; Laboratory of Comparative Pathology, Weill Cornell Medicine, Memorial Sloan Kettering Cancer Center and Rockefeller University, New York, NY 10065, USA.
Norah A OwitiDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA 01239, USA.
Lee J PribylDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA 01239, USA.
Ilana S NazariDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Dorothea K TorousLitron Laboratories, Rochester, NY 14623, USA.
Svetlana L AvlasevichLitron Laboratories, Rochester, NY 14623, USA.
Robert G CroyDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA 01239, USA; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 01239, USA.
Dushan N WadduwageThe John Harvard Distinguished Science Fellows Program, Harvard University, Cambridge, MA 02138, USA; Center for Advanced Imaging, Harvard University, Cambridge, MA 02138, USA.
Sebastian E CarrascoLaboratory of Comparative Pathology, Weill Cornell Medicine, Memorial Sloan Kettering Cancer Center and Rockefeller University, New York, NY 10065, USA.
Stephen D DertingerLitron Laboratories, Rochester, NY 14623, USA.
John M EssigmannDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA 01239, USA; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 01239, USA.
Leona D SamsonDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA 01239, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 01239, USA.
Bevin P EngelwardDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA 01239, USA.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
TOXICOLOGY CORE UNITP30ES002109 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI NILES, JACQUIN C · 1985 to 2020
$25.6M
The MIT Superfund Research Program: A Systems Approach for the Protection of Human Health from Hazardous ChemicalsP42ES027707 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Stuart S Levine · 2017 to 2026
$22.2M
TRAINING GRANTS IN ENVIROMENTAL TOXICOLOGYT32ES007020 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ESSIGMANN, JOHN M · 1985 to 2024
$13.1M
Wide-Field Short-Wave Infrared (SWIR) multiphoton (MP) tissue imagingP41EB015871 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SO, PETER T. · 2012 to 2021
$11.3M
Intra and Extra-Chromosomal Probes for Mutagenesis by CarcinogensR01CA080024 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ESSIGMANN, JOHN M · 1998 to 2025
$5.9M
Automation of a Liver Genotoxicity AssayR44ES026464 · NIEHS · LITRON LABORATORIES, LTD. · PI BEMIS, JEFFREY C, DERTINGER, STEPHEN D · 2016 to 2018
$1.1M
Quantifying early biomarkers of mammary carcinogenesis with multiplexed spatial biologyK01ES036182 · NIEHS · SILENT SPRING INSTITUTE · PI Jennifer Kay · 2024 to 2026
$469k
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA080024NIBIB NIH HHS P41 EB015871NIEHS NIH HHS K01 ES036182NIEHS NIH HHS P30 ES002109NIEHS NIH HHS P42 ES027707NIEHS NIH HHS R44 ES026464NIEHS NIH HHS T32 ES007020
6 · The paper itself

Abstract

N-Nitrosodimethylamine (NDMA) is present in food, water, and drugs and is considered a probable human carcinogen by the International Agency for Research on Cancer. The mechanism of action of NDMA involves the generation of carcinogenic methyl lesions such as 3-methyladenine (3MeA) on DNA bases. Alkyladenine DNA Glycosylase (AAG; a.k.a. N-methylpurine DNA glycosylase, MPG) removes 3MeA to initiate Base Excision Repair, leaving an abasic site that is resolved by backbone cleavage, nucleotide insertion, and backbone ligation. The intermediate steps following base removal produce potentially toxic and mutagenic abasic sites and single-strand DNA breaks. Here, we explored differences between males and females regarding downstream DNA damage, toxicity, mutations and cancer arising from 3MeA in the livers of WT, Aag

Indexed as

DimethylnitrosamineDNA GlycosylasesExcision RepairLiver NeoplasmsMutationAlkylationAnimalsDNA DamageFemaleLiverMaleMiceSex Factors3-methyladenine-DNA glycosylaseDimethylnitrosamineDNA GlycosylasesAlkyladenine DNA GlycosylaseCarcinogenesisDNA damageGene-environment interactionMutagenesisN-nitrosodimethylamineSex-related differences

Identifiers

PMID42566817
PMCPMC13613344

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.