In one paragraphArticle in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
32 authors.
Kevin M TharpCancer Metabolism and Microenvironment Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.ORCID 0000-0002-3543-3266 Greg A TimblinCenter for Bioengineering and Tissue Regeneration, Department of Surgery, University of California, San Francisco, CA 94143, USA.ORCID 0000-0001-9351-3646 Alicia L RichardsQuantitative Biosciences Institute (QBI) and Department of Cellular and Molecular Pharmacology, University of California, and J. David Gladstone Institutes, San Francisco, CA 94158, USA.
Nicholas M TwellsDepartment of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada.
Nicholas M RileyDepartment of Chemistry, Sarafan ChEM-H, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-1536-2966 Kyle AlvarezCancer Metabolism and Microenvironment Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.ORCID 0009-0004-6956-7141 Allen LeeCancer Metabolism and Microenvironment Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Egan L PeltanDepartment of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305 USA.ORCID 0009-0004-4635-7782 D Judy ShonDepartment of Chemistry, Sarafan ChEM-H, Stanford University, Stanford, CA 94305, USA.
Erica StevensonQuantitative Biosciences Institute (QBI) and Department of Cellular and Molecular Pharmacology, University of California, and J. David Gladstone Institutes, San Francisco, CA 94158, USA.ORCID 0000-0001-7853-1854 Kimberly TsuiDepartment of Molecular and Cellular Biology and Howard Hughes Medical Institute, University of California, Berkeley, CA 94597, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, CA 94158, USA; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94158, USA; Gladstone Institute of Data Science and Biotechnology, J. David Gladstone Institutes, San Francisco, CA 94158, USA.ORCID 0000-0002-3807-5329 Francesco PalombaLaboratory for Fluorescence Dynamics, Department of Biomedical Engineering, University of California, Irvine, CA 92697, USA.
Jaya L ThangarajDivision of Regenerative Medicine, Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-4242-873X Nadia M E AyadCenter for Bioengineering and Tissue Regeneration, Department of Surgery, University of California, San Francisco, CA 94143, USA.ORCID 0000-0002-4684-1943 Joseph A RhodenhiserCancer Metabolism and Microenvironment Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Johanna Ten HoeveUCLA Metabolomics Center, Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0003-0226-749X Kevin HealyDepartment of Bioengineering and Department of Materials Science and Engineering, University of California, Berkeley, CA 94720, USA.ORCID 0000-0002-8524-3671 Michelle DigmanLaboratory for Fluorescence Dynamics, Department of Biomedical Engineering, University of California, Irvine, CA 92697, USA.ORCID 0000-0003-4611-7100 Andrew DillinDepartment of Molecular and Cellular Biology and Howard Hughes Medical Institute, University of California, Berkeley, CA 94597, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, CA 94158, USA; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94158, USA; Gladstone Institute of Data Science and Biotechnology, J. David Gladstone Institutes, San Francisco, CA 94158, USA.ORCID 0000-0002-7427-2629 Nevan J KroganQuantitative Biosciences Institute (QBI) and Department of Bioengineering and Therapeutic Sciences, University of California, and Gladstone Institute of Data Science and Biotechnology, J. David Gladstone Institutes, San Francisco, CA 94158, USA.ORCID 0000-0003-4902-337X Carolyn R BertozziDepartment of Chemical and Systems Biology, Sarafan ChEM-H and Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0003-4482-2754 Dan S KaufmanDivision of Regenerative Medicine, Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-2003-2494 Sanju SinhaCancer Metabolism and Microenvironment Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.ORCID 0000-0002-2688-0603 Danielle L SwaneyQuantitative Biosciences Institute (QBI) and Department of Cellular and Molecular Pharmacology, University of California, and J. David Gladstone Institutes, San Francisco, CA 94158, USA.ORCID 0000-0001-6119-6084 Matthew J PaszekRobert Frederick Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY 14850, USA.ORCID 0000-0003-0064-9400 Valerie M WeaverCenter for Bioengineering and Tissue Regeneration, Department of Surgery, University of California, San Francisco, CA 94143, USA.ORCID 0000-0003-4786-6752 Funding
Tumor Microenvironment and Cancer ImmunologyP30CA030199 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI ELENA B PASQUALE · 1985 to 2026
$107.2MThe Cancer Cell Map Initiative v2.0U54CA274502 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Emma Lundberg · 2022 to 2026
$14.2MTissue mechanics reprograms the tissue to malignancy and metastasisR35CA242447 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VALERIE MARIE WEAVER · 2020 to 2026
$6.6MTargeting the Cancer GlycocalyxR01CA227942 · NCI · STANFORD UNIVERSITY · PI Carolyn Bertozzi · 2019 to 2026
$3.6MTension-Stat3-miR-mediated metastasisR01CA192914 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SEEWALDT, VICTORIA L., WEAVER, VALERIE MARIE · 2015 to 2019
$2.9MTissue Tension, RANK and Breast Cancer RiskR01CA222508 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HWANG, E.SHELLEY, WEAVER, VALERIE MARIE · 2018 to 2022
$2.8MPhysical Resistance to Immune Cell Attack by the Cellular GlycocalyxR01CA276398 · NCI · CORNELL UNIVERSITY · PI Matthew J Paszek · 2023 to 2026
$1.8MAcquisition of Zeiss LSM980 with Airyscan 2, a super-resolution point scanning confocal microscopeS10OD032408 · OD · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI KAUFMAN, RANDAL J. · 2023 to 2023
$600kWide-field super-resolution spinning disk confocal microscopeS10OD028611 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WITTMANN, TORSTEN · 2020 to 2020
$600kMechanical stress reprograms mitochondrial metabolism to support tumor survival and invasion through the mitochondrial unfolded protein responseF32CA236156 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI THARP, KEVIN · 2019 to 2021
$110kCapturing the Holistic Glycocode through Systems GlycobiologyK99GM147304 · NIGMS · STANFORD UNIVERSITY · PI RILEY, NICHOLAS M · 2022 to 2022
$100kContextualizing Chaotic Metabolic Networks and Their RegulationF99CA253744 · NCI · UNIVERSITY OF UTAH · PI BERG, JORDAN ALEXANDER · 2020 to 2021
$73kNCI NIH HHS F32 CA236156NCI NIH HHS F99 CA253744NCI NIH HHS P30 CA030199NCI NIH HHS R01 CA192914NCI NIH HHS R01 CA222508NCI NIH HHS R01 CA227942NCI NIH HHS R01 CA276398NCI NIH HHS R35 CA242447NCI NIH HHS U54 CA274502NIGMS NIH HHS K99 GM147304NIH HHS S10 OD028611NIH HHS S10 OD032408
6 · The paper itselfAbstract
Altered glucose metabolism is an auspicious feature of solid tumors, but is it an intrinsic property of tumor cells or a metabolic adaptation to the tumor microenvironment? Using normal epithelial cells cultured in a physiological culture medium under conditions that mimic the physical properties of healthy or cancerous tissues, we establish multiomics relationships between the biochemical and physical properties of the microenvironment and its impact on biosynthetic outputs of altered glucose metabolism. We find that microenvironmental properties, such as hyperglycemia, can affect the composition and thickness of the epithelial glycocalyx, in part through the activity of mechanosensitive stress responses associated with Heat Shock Factor 1 (HSF1). Because glycocalyx thickness alters immune surveillance of epithelial-origin tumor cells, we examined the relationship between the HSF1-hyperglycemia axis in human breast tumors and validate it as a druggable vulnerability to license natural killer cell lethality against cancer cells.
Indexed as
Breast NeoplasmsHeat Shock Transcription FactorsImmunologic SurveillanceTumor MicroenvironmentCell Line, TumorFemaleGlucoseGlycocalyxHumansMetabolic ReprogrammingGlucoseHeat Shock Transcription FactorsHSF1 protein, human
Identifiers
PMID42566549
PMCPMC13450322
What OpenQuestion holds
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LicenceCC BY-NC
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