Evidence map›Paper›PMID 42566543›Full record

ArticleScience advances2026

Formation of tertiary lymphoid structures drives Parkin antitumor immunity.

Michela Perego, Andrew V Kossenkov, Jagadish C Ghosh, Chiara Camisaschi, Nicholas J Tursi, David B Weiner, Dario C Altieri

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Michela PeregoGenome Regulation and Cell Signaling Program, The Wistar Institute, Philadelphia, PA 19104.ORCID 0000-0002-5671-928X
Andrew V KossenkovGenome Regulation and Cell Signaling Program, The Wistar Institute, Philadelphia, PA 19104.ORCID 0000-0002-1536-0418
Jagadish C GhoshGenome Regulation and Cell Signaling Program, The Wistar Institute, Philadelphia, PA 19104.ORCID 0000-0002-1832-4578
Chiara CamisaschiFlow Cytometry Core, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.ORCID 0000-0002-5205-919X
Nicholas J TursiVaccine and Immunotherapy Center, The Wistar institute, Philadelphia, PA 19104.ORCID 0000-0001-6752-3402
David B WeinerVaccine and Immunotherapy Center, The Wistar institute, Philadelphia, PA 19104.ORCID 0000-0002-2232-8512
Dario C AltieriGenome Regulation and Cell Signaling Program, The Wistar Institute, Philadelphia, PA 19104.ORCID 0000-0002-0617-3469

Funding

Tumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Aaron Robert Goldman · 1985 to 2026
$75.9M
Tumor PlasticityR35CA220446 · NCI · WISTAR INSTITUTE · PI ALTIERI, DARIO C · 2017 to 2023
$7.7M
Parkin tumor suppressionR01CA286080 · NCI · WISTAR INSTITUTE · PI Dario C Altieri · 2024 to 2026
$2.5M
Integrative Approach to Comprehensive Analysis of High Throughput Data on a Cancer Center LevelR50CA211199 · NCI · WISTAR INSTITUTE · PI Andrew V Kossenkov · 2016 to 2026
$1.6M
Purchase of a Q Exactive HF mass spectrometer system for metabolomicsS10OD023586 · OD · WISTAR INSTITUTE · PI SPEICHER, DAVID W. · 2017 to 2017
$600k
NCI NIH HHS P30 CA010815NCI NIH HHS R01 CA286080NCI NIH HHS R35 CA220446NCI NIH HHS R50 CA211199NIH HHS S10 OD023586
6 · The paper itself

Abstract

Mitochondria activate immunity, but the role in cancer is unknown. Here, we report that transgenic expression of Parkin, a regulator of mitochondrial fitness, induces inflammation and interferon (IFN) gene signatures, suppresses prostate cancer formation and generates CD8

Indexed as

Prostatic NeoplasmsTertiary Lymphoid StructuresUbiquitin-Protein LigasesAnimalsB-LymphocytesHumansMaleMiceMitochondriaparkin proteinUbiquitin-Protein Ligases

Identifiers

PMID42566543
PMCPMC13450316

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.