Evidence map›Paper›PMID 42566536›Full record

ArticleScience advances2026

Ly6d expression delineates two putative postnatal thymus epithelial progenitor cells that are differentially affected by aging.

Irene Calvo-Asensio, Andreas Tarcevski, Fatima Dhalla, Anja Kusch, Thomas Barthlott, Saulius Zuklys, Georg A Holländer, Michael D Morgan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Irene Calvo-AsensioDepartment of Biomedicine, University of Basel and University Children's Hospital, Basel, Switzerland.ORCID 0000-0002-9356-6008
Andreas TarcevskiInstitute of Developmental and Regenerative Medicine, University of Oxford, Oxford, UK.ORCID 0009-0008-9787-5458
Fatima DhallaInstitute of Developmental and Regenerative Medicine, University of Oxford, Oxford, UK.ORCID 0000-0001-9244-2284
Anja KuschDepartment of Biomedicine, University of Basel and University Children's Hospital, Basel, Switzerland.ORCID 0009-0009-8692-5170
Thomas BarthlottDepartment of Biomedicine, University of Basel and University Children's Hospital, Basel, Switzerland.
Saulius ZuklysDepartment of Biomedicine, University of Basel and University Children's Hospital, Basel, Switzerland.
Georg A HolländerDepartment of Biomedicine, University of Basel and University Children's Hospital, Basel, Switzerland.ORCID 0000-0002-8790-0874
Michael D MorganInstitute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Foresterhill, Aberdeen, UK.ORCID 0000-0003-0757-0711

Funding

Wellcome Trust
6 · The paper itself

Abstract

To date, the identity and maintenance of postnatal thymic epithelial progenitor cells (TEPCs) remain unclear, as does the persistence of bipotent TEPCs after birth or whether lineage-restricted progenitors independently maintain separate TEC compartments. Using an inducible lineage-tracing system based on expression of the thymoproteasomal protein β5t, which is expressed in embryonic and a subset of postnatal TEPCs, we explored the early dynamics of the relationships between thymic epithelial cell (TEC) progenitors and their progeny. Our results identified two potential lineage-biased progenitor subpopulations, distinguished by

Indexed as

AgingAntigens, LyEpithelial CellsStem CellsThymus GlandAnimalsCell DifferentiationCell LineageMiceAntigens, Ly

Identifiers

PMID42566536
PMCPMC13450219

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.