Evidence map›Paper›PMID 42566533›Full record

ArticleScience advances2026

Structural insights into a substrate translocation pathway revealed by the RND efflux pump complex MexJK from

Zhikun Wu, Ziyue Meng, Wei Huang, Zhaoxiao Yu, Longtao Cao, Jie Wang, Zhipeng Xie, Meng Cui, Luyan Z Ma, Feng Long

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zhikun WuMinistry of Education Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China.ORCID 0009-0005-1957-3540
Ziyue MengDepartment of Pharmaceutical Sciences, Northeastern University School of Pharmacy, Boston, MA 02115, USA.ORCID 0009-0008-8259-7117
Wei HuangCollege of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430061, China.ORCID 0009-0005-4519-910X
Zhaoxiao YuInstitute of Microbiology, Academy of Agricultural Sciences of Xinjiang Uyghur Autonomous Region, Urumqi 830091, China.ORCID 0000-0003-4810-0580
Longtao CaoMinistry of Education Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China.
Jie WangMinistry of Education Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China.
Zhipeng XieMinistry of Education Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China.ORCID 0000-0001-6882-3300
Meng CuiDepartment of Pharmaceutical Sciences, Northeastern University School of Pharmacy, Boston, MA 02115, USA.ORCID 0000-0002-3895-135X
Luyan Z MaState Key Laboratory of Microbial Diversity and Innovative Utilization, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.ORCID 0000-0002-3837-6682
Feng LongMinistry of Education Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China.ORCID 0000-0001-6313-8558

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Resistance-nodulation-cell division (RND) efflux pumps are the major cause of multidrug resistance in

Indexed as

Bacterial ProteinsMembrane Transport ProteinsPseudomonas aeruginosaBacterial Outer Membrane ProteinsBinding SitesBiological TransportCryoelectron MicroscopyModels, MolecularMolecular Dynamics SimulationProtein BindingProtein ConformationTriclosanBacterial Outer Membrane ProteinsBacterial ProteinsMembrane Transport ProteinsTriclosan

Identifiers

PMID42566533
PMCPMC13450314

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.