Evidence map›Paper›PMID 42566532›Full record

ArticleScience advances2026

MBNL1 hijacks a structured single-stranded distal DNA element to sustain

Meixia Che, Shaela Fields, Siqi Yi, Judith Hyle, Mengli Zhang, Beisi Xu, Yong Cheng, Peng Xu, Yajun Jiang, Chunliang Li

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Meixia CheState Key Laboratory of Pharmaceutical Biotechnology, Department of Oncology, Nanjing Drum Tower Hospital, School of Life Sciences, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, 210023 Nanjing, China.ORCID 0000-0002-4515-1414
Shaela FieldsDivision of Molecular Oncology/Cancer Biology Program, Comprehensive Cancer Center, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0003-2213-5515
Siqi YiDepartment of Hematology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Judith HyleDivision of Molecular Oncology/Cancer Biology Program, Comprehensive Cancer Center, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Mengli ZhangCyrus Tang Medical Institute, National Clinical, Research Center for Hematologic Disease, State Key Laboratory of Radiation Medicine and Protection, Collaborative Innovation Center of Hematology, Suzhou Medical College, Soochow University, 215123 Suzhou, Jiangsu, China.ORCID 0009-0008-0801-485X
Beisi XuCenter for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0003-0099-858X
Yong ChengDepartment of Hematology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Peng XuCyrus Tang Medical Institute, National Clinical, Research Center for Hematologic Disease, State Key Laboratory of Radiation Medicine and Protection, Collaborative Innovation Center of Hematology, Suzhou Medical College, Soochow University, 215123 Suzhou, Jiangsu, China.ORCID 0000-0002-7573-4813
Yajun JiangState Key Laboratory of Pharmaceutical Biotechnology, Department of Oncology, Nanjing Drum Tower Hospital, School of Life Sciences, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, 210023 Nanjing, China.ORCID 0000-0002-0886-292X
Chunliang LiDivision of Molecular Oncology/Cancer Biology Program, Comprehensive Cancer Center, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0002-5938-5510

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The molecular mechanisms by which KMT2A-rearranged (KMT2A-r) leukemias maintain the oncogenic

Indexed as

DNA, Single-Strandedfms-Like Tyrosine Kinase 3Gene Expression Regulation, LeukemicGene RearrangementHistone-Lysine N-MethyltransferaseLeukemiaMyeloid-Lymphoid Leukemia ProteinRNA-Binding ProteinsCell Line, TumorHumansProtein BindingDNA, Single-StrandedFLT3 protein, humanfms-Like Tyrosine Kinase 3Histone-Lysine N-MethyltransferaseKMT2A protein, humanMyeloid-Lymphoid Leukemia ProteinRNA-Binding Proteins

Identifiers

PMID42566532
PMCPMC13450212

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.