ArticlePloS one2026
Hemodynamic, neurological, and cognitive outcomes after surgical revascularisation in occlusive cerebrovascular disease: Study protocol for single-arm interventional cohort study.
Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07396025 (Evaluation of the Effectiveness of Surgical and Diagnostic Techniques in Patients With Steno-occlusive Diseases of the Cerebral Vessels), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Evaluation of the Effectiveness of Surgical and Diagnostic Techniques in Patients With Steno-occlusive Diseases of the Cerebral Vessels
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9 authors.
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Abstract
backgroundChronic carotid artery occlusive disease is associated with a high risk of ischemic events and long-term neurological deficits. Optimising surgical revascularisation outcomes requires an integrated understanding of anatomical, hemodynamic, and functional factors. This study aims to assess the neuro-radiological, clinical, and cognitive outcomes following cerebral revascularisation in patients with chronic internal carotid artery occlusion.
methodsThis single-centre, prospective, open-label interventional longitudinal study includes 60 patients with chronic internal carotid artery occlusion undergoing superficial temporal artery-to-middle cerebral artery (STA-MCA) bypass at National Centre for Neurosurgery in Kazakhstan. The primary endpoint of the study is the incidence of ischemic stroke during the 6-month follow-up period after surgery. Pre- and postoperative evaluations include detailed angiographic assessment of collateral circulation and donor vessel diameter, as well as cerebral perfusion imaging using arterial spin labelling MRI. Neurological and cognitive function are assessed using standardized clinical and neuropsychological tests. Early and six-month follow-up evaluations focus on bypass patency, perfusion changes, and clinical outcomes. DISCUSSION: By integrating anatomical, hemodynamic, and functional data, this study aims to identify predictors of successful revascularisation and favorable clinical outcomes. Correlation of postoperative angiographic and perfusion findings with cognitive and neurological recovery may refine surgical decision-making, enhance risk stratification, and optimize individualized patient care. Ultimately, this comprehensive approach seeks to improve the overall efficacy and safety of STA-MCA bypass in patients with chronic carotid artery occlusive disease.
trial registrationClinicalTrials.gov NCT07396025. Registered on February 5, 2026.
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