Evidence map›Paper›PMID 42566146›Full record

ArticleMolecular and cellular biochemistry2026

METTL3 promotes proliferation and invasion and inhibits ferroptosis in hepatocellular carcinoma by mediating m6A methylation modification of NUPR1.

Yushan Zhao, Zhiyu Nan, Haojie Feng, Dong Wang

Abstract read
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In one paragraph

Article in Molecular and cellular biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yushan ZhaoDepartment of Interventional Therapy, Shanxi Province Cancer Hospital/ Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, No. 3, Zhigongxin Village, Xinghualing District, Taiyuan, 030013, Shanxi, China.
Zhiyu NanDepartment of Interventional Therapy, Shanxi Province Cancer Hospital/ Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, No. 3, Zhigongxin Village, Xinghualing District, Taiyuan, 030013, Shanxi, China.
Haojie FengDepartment of Interventional Therapy, Shanxi Province Cancer Hospital/ Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, No. 3, Zhigongxin Village, Xinghualing District, Taiyuan, 030013, Shanxi, China.
Dong WangDepartment of Interventional Therapy, Shanxi Province Cancer Hospital/ Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, No. 3, Zhigongxin Village, Xinghualing District, Taiyuan, 030013, Shanxi, China. wangdong202601@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

N6-methyladenosine (m6A) methylation modification plays an essential role in cancer development. This study focused on the mechanism exploration of m6A methyltransferase 3 (METTL3) and its downstream target gene nuclear protein-1 (NUPR1) in hepatocellular carcinoma (HCC). Detection of mRNA and protein was completed using real-time quantitative polymerase chain reaction and Western blot. Cellular behaviors were evaluated by CCK-8, EdU, flow cytometry and transwell assay. Ferroptosis was analyzed via Fe

Indexed as

Hepatocellular carcinomaMethyltransferase 3N6-methyladenosine (m6A) methylationNuclear protein-1

Identifiers

PMID42566146

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.