ArticleMolecular and cellular biochemistry2026
Effect of melatonin treatment on oxidative stress-related parameters in REM sleep-deprived rats.
Article in Molecular and cellular biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Rapid eye movement sleep deprivation (REM-SD) is associated with increased oxidative stress, characterized by disruption of the oxidant-antioxidant balance and accumulation of reactive oxygen species (ROS). Melatonin may act as a potential modulator of REM-SD-associated oxidative alterations through its circadian regulatory effects, direct ROS scavenging activity, and support of endogenous antioxidant defense mechanisms. This study aimed to evaluate the effects of melatonin treatment administered during the six-day REM-SD period or during the recovery period following REM-SD on oxidative stress-related parameters in 8-12-week-old male Sprague-Dawley rats (n = 84). REM-SD was induced using the modified multiple platform method (MMPM). Biochemical markers reflecting oxidative balance, including total antioxidant status (TAS), total oxidant status (TOS), the lipid peroxidation product malondialdehyde (MDA), non-enzymatic antioxidant glutathione (GSH), and enzymatic antioxidants, including catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) levels, were assessed using the enzyme-linked immunosorbent assay (ELISA). The findings demonstrated that REM-SD predominantly affected enzymatic antioxidant defense-related parameters. Melatonin modulated these responses, mainly by increasing enzymatic antioxidant levels and reducing lipid peroxidation. However, no significant change was observed in TOS, whereas the effect on TAS was limited and time-dependent. During the recovery period, several oxidative stress markers partially normalized, indicating a possible reactivation of endogenous antioxidant defenses. In conclusion, six-day MMPM-induced REM-SD appears to alter oxidative stress-related parameters, while melatonin may help attenuate some of these alterations by modulating antioxidant defense mechanisms. These effects varied according to the timing of administration and the specific parameter examined.
Indexed as
Identifiers
42566144What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.