Evidence map›Paper›PMID 42566102›Full record

ArticleCell regeneration (London, England)2026

Species-specific functions of CSRP3 in satellite cell-driven muscle regeneration and relevance to porcine stem cell therapy.

Li Zhang, Wenya Li, Mingli Zhu, Hanyuhui Yang, Yilina Bai, Bing Sun, Yiming Xing

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell regeneration (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Li Zhang *State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Wenya Li *State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Mingli ZhuState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Hanyuhui YangState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Yilina BaiState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Bing SunState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Yiming XingState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China. ymxing@cau.edu.cn.ORCID http://orcid.org/0000-0001-9434-0273

Funding

Biological Breeding Major Project 2023ZD0407106Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions 23KJB230002
6 · The paper itself

Abstract

backgroundSkeletal muscle function deteriorates with injury, disease, or aging. While stem cell therapies offer therapeutic potential, concerns remain regarding the safety and efficacy of transplanted cells. Satellite cells (SCs), the primary endogenous stem cells responsible for muscle repair, demonstrate safe transplantation but limited clinical effectiveness. A deeper understanding of the mechanisms regulating SC activation and differentiation is critical for improving muscle regeneration strategies.

methodsWe examined the role of CSRP3 in SC-mediated muscle repair using injury models and myoblast differentiation assays. We compared its function in pigs and mice, employing genetic approaches, CSRP3 knockdown (CSRP3

resultsCSRP3 was essential for muscle regeneration and SC differentiation in pigs but not in mice. Genetic ablation of CSRP3 (CSRP3

conclusionsOur findings identify CSRP3 as a critical regulator of porcine muscle regeneration, with minimal impact in mice. These results suggest that strategically engineered porcine SCs, through CSRP3 modulation, could improve the effectiveness of xenotransplantation-based therapies for muscle repair.

Indexed as

AKT-SERCA2 pathwayCSRP3Satellite cellsSkeletal muscle regeneration

Identifiers

PMID42566102
PMCPMC13451472

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.