ArticleArchives of microbiology2026
Host Gnmt coordinates with Limosilactobacillus reuteri to alleviate ionizing radiation injury via microbiota remodeling and metabolic regulation in Drosophila melanogaster.
Article in Archives of microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Organismal health is dictated by the interplay between host genetics, microbiota, and environmental stressors like ionizing radiation (IR). However, the role of potential metabolic factors, such as Glycine N-methyltransferase (Gnmt), in coordinating this stress response remains largely unexplored. We aimed to investigate whether a candidate host factor, Gnmt, contributes to the radioprotective effects of Limosilactobacillus reuteri (L. reuteri) and to elucidate their coordination in mitigating IR damage. Label-free proteomics identified IR-responsive proteins. Gnmt function was interrogated using genetic manipulation to assess its impact on apoptosis, triacylglycerol (TAG) and free fatty acid (FFA) utilization, and lifespan. Radioprotective effects of two L. reuteri strains (DSM 17938 and ATCC PTA-6475) were evaluated in wild-type and gnmt mutant flies, with microbiota changes analyzed by 16 S rRNA sequencing. Proteomics identified Gnmt as a potential regulator of IR-induced apoptosis and lipid mobilization. Gnmt overexpression extended post-IR lifespan in both sexes. L. reuteri supplementation suppressed IR-induced apoptosis through a pathway that appears Gnmt-independent. However, while strain DSM 17,938 extended lifespan regardless of Gnmt, strain ATCC PTA-6475 required host Gnmt for radioprotection in males. Beta-diversity analysis demonstrated that L. reuteri moved microbial community structures more closely to non-irradiated controls. This involved suppressing potentially opportunistic Enterobacter and promoting commensal Lactobacillus, effects that were largely contingent upon host Gnmt. L. reuteri supplementation improves survival and suppresses apoptosis in irradiated flies. While cellular protection appears Gnmt-independent, systemic microbiota restoration is associated with host Gnmt function. This suggests a dual-track protective mechanism involving both host-Gnmt-coordinated microbiota remodeling and parallel cellular protection pathways.
Indexed as
Identifiers
42566035What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.