Evidence map›Paper›PMID 42566029›Full record

ArticleSurgery today2026

Prior cholecystectomy may identify a biologically aggressive subset of RAS-mutated proximal colon cancer: A 13-year retrospective cohort study.

Masashi Tsunematsu, Koichiro Haruki, Mitsuru Yanagaki, Yoshihiro Shirai, Yoshiaki Tanji, Shinji Onda, Tomohiko Taniai, Michinori Matsumoto, Kenei Furukawa, Toru Ikegami

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Article in Surgery today, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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5 · Who and what money

Authors and funding

10 authors.

Masashi TsunematsuDepartment of Digestive Surgery, Saku Central Hospital Advanced Care Center, Nakagomi, Saku, Nagano, 3400-28, 385-0051, Japan.
Koichiro HarukiDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan. haruki@jikei.ac.jp.ORCID http://orcid.org/0000-0002-1686-3228
Mitsuru YanagakiDepartment of Digestive Surgery, Saku Central Hospital Advanced Care Center, Nakagomi, Saku, Nagano, 3400-28, 385-0051, Japan.
Yoshihiro ShiraiDepartment of Digestive Surgery, Saku Central Hospital Advanced Care Center, Nakagomi, Saku, Nagano, 3400-28, 385-0051, Japan.
Yoshiaki TanjiDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan.
Shinji OndaDepartment of Digestive Surgery, Saku Central Hospital Advanced Care Center, Nakagomi, Saku, Nagano, 3400-28, 385-0051, Japan.
Tomohiko TaniaiDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan.
Michinori MatsumotoDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan.
Kenei FurukawaDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan.
Toru IkegamiDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposesCholecystectomy (CCY) may influence the colorectal cancer (CRC) outcomes in a location-specific manner. We investigated the association between CCY history and RAS mutations in CRC, focusing on tumor location.

methodsWe retrospectively analyzed 1,340 patients with CRC diagnosed between 2012 and 2024, with an available RAS mutation status. Patients were classified into proximal and distal groups for analysis. The survival outcomes were compared using multivariate Cox proportional hazard regression models.

resultsCCY was associated with a higher RAS mutation prevalence in proximal CRC (58% vs. 48%) but a lower prevalence in distal CRC (30% vs. 44%). The coexistence of a history of CCY and RAS mutations was associated with worse OS in proximal CRC (p = 0.025), but not in distal CRC (p = 0.212). Among patients with proximal CRC, a multivariate analysis revealed that TNM stage III/IV (p < 0.001), non-resection initial strategy (p < 0.001), and coexistence of history of CCY and RAS mutation (p = 0.008) were independent predictors of poor OS.

conclusionsCCY had opposite effects on RAS mutation prevalence according to tumor location and, in combination with RAS mutation, identified a high-risk subgroup in proximal CRC. These findings suggest a location-specific phenomenon linking environmental changes to tumor biology. (192 words).

Indexed as

CholecystectomyColorectal cancerPrognosisRAS mutationTumor location

Identifiers

PMID42566029

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