Evidence map›Paper›PMID 42565908›Full record

ArticleTranslational stroke research2026

Association of Traditional and Novel Lipid Indicators With the Hemorrhagic Phenotype in Adult Moyamoya Disease: Implications for Phenotype Stratification.

Weihong Huang, Haoyang Xiong, Wenjing Chen, Wei Liu, Peicong Ge, Yunhao Liu, Xuefeng Tang, Ziheng Yang, Zhongji Yan, Dong Zhang

Abstract readMulticenter Study
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In one paragraph

Article in Translational stroke research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Weihong HuangDepartment of Neurosurgery, National Center for Gerontology; National Clinical Research Center for Gerontology; The Key Laboratory of Geriatrics of NHC; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital, Beijing, China.
Haoyang XiongDepartment of Neurosurgery, National Center for Gerontology; National Clinical Research Center for Gerontology; The Key Laboratory of Geriatrics of NHC; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital, Beijing, China.
Wenjing ChenSchool of Clinical Medical Sciences, Southwest Medical University, China, China.
Wei LiuDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Peicong GeDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Yunhao LiuSchool of Clinical Medical Sciences, Southwest Medical University, China, China.
Xuefeng TangSchool of Clinical Medical Sciences, Southwest Medical University, China, China.
Ziheng YangSchool of Clinical Medical Sciences, Southwest Medical University, China, China.
Zhongji YanSchool of Clinical Medical Sciences, Southwest Medical University, China, China.
Dong ZhangDepartment of Neurosurgery, National Center for Gerontology; National Clinical Research Center for Gerontology; The Key Laboratory of Geriatrics of NHC; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital, Beijing, China. zhangdong0660@aliyun.com.

Funding

Beijing Hospital BJ-2024-143
6 · The paper itself

Abstract

To investigate the associations of traditional and novel lipid parameters with the hemorrhagic phenotype in adults with primary moyamoya disease (MMD) and to evaluate their value for phenotype discrimination and stratification. This retrospective dual-center cross-sectional study included 1,176 adults with primary MMD treated at Beijing Hospital and Beijing Tiantan Hospital between January 2022 and January 2026, including 857 patients with a non-hemorrhagic phenotype and 319 with a hemorrhagic phenotype. Traditional and derived lipid parameters were analyzed. Missing body mass index values were handled using multiple imputation. Multivariable logistic regression, restricted cubic spline analysis, receiver operating characteristic analysis, incremental discrimination analysis, sensitivity analyses, subgroup analyses, and exploratory mediation analysis were performed. Compared with patients with the non-hemorrhagic phenotype, those with the hemorrhagic phenotype had lower body mass index and higher levels of several cholesterol-related lipid parameters. In fully adjusted models, total cholesterol, low-density lipoprotein cholesterol, and non-high-density lipoprotein cholesterol were significantly associated with the hemorrhagic phenotype, with odds ratios for the highest versus lowest quartile of 3.435, 3.197, and 3.150, respectively. These indicators showed modest individual discriminative ability and provided limited incremental improvement when added to the basic clinical model. Sensitivity and subgroup analyses were generally consistent. Exploratory analyses identified BMI-related negative indirect effects. Cholesterol-related lipid parameters, particularly total cholesterol, low-density lipoprotein cholesterol, and non-high-density lipoprotein cholesterol, were associated with the hemorrhagic phenotype in adult primary MMD and may serve as supplementary markers for phenotype stratification.

Indexed as

LipidsMoyamoya DiseaseAdultCholesterolCross-Sectional StudiesFemaleHumansMaleMiddle AgedPhenotypeRetrospective StudiesCholesterolLipidsHemorrhagic phenotypeLipid parametersMmoyamoya diseaseNon-HDL cholesterolPhenotype stratification

Identifiers

PMID42565908

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