SynthesisInternational ophthalmology2026
Global mortality of glaucoma: a systematic review and meta-analysis of prospective studies.
Synthesis in International ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo quantify the mortality and relative mortality risk of glaucoma and its subtypes through a systematic review and meta-analysis.
methodsWe identified prospective studies reporting glaucoma mortality published from January 1, 1990 to August 9, 2025. Data on absolute mortality and relative mortality risk of primary open-angle glaucoma (POAG), primary angle-closure glaucoma (PACG), and congenital glaucoma were extracted. The absolute mortality was reported either as cumulative mortality or mortality rate, and the relative mortality risk was reported as hazard ratio (HR), risk ratio (RR), or odds ratio (OR). The annual cumulative mortality (ACM) of POAG was transformed from cumulative mortality and pooled using a random-effects meta-analysis. Unadjusted and fully adjusted HRs of mortality risk comparing people with and without POAG were also pooled using random-effects meta-analyses.
resultsSeven articles were included. The pooled ACM of POAG was 3.42% (95% confidence interval [CI] 1.70%-5.58%). The mortality rate of POAG was reported in one study as 6.1 (95% CI 5.5-6.7) per 1000 person-years. A significant association between POAG and mortality was observed in the pooled unadjusted relative mortality risk estimates (HR 2.14, 95% CI 1.32-3.47). Fully adjusted relative mortality risk estimates did not show a significant association with mortality (HR 1.13, 95% CI 0.91-1.40). The cumulative mortality of PACG over ten years (47.6%, 95% CI 25.7%-70.2%) and the cumulative mortality of congenital glaucoma over 15 years (3.48%) were reported.
conclusionIn the context of global aging, integrating glaucoma care with comprehensive management of systemic health may help improve long-term outcomes among individuals with glaucoma. More prospective studies are needed to provide a basis for allocating resources for eye health care.
Indexed as
Identifiers
42565899What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.