In one paragraphArticle in The Journal of experimental medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
33 authors.
Ja-Hyun Koo *Batista Lab, The Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA, USA.ORCID 0000-0002-0291-6288 Yevel Flores-GarciaDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.ORCID 0000-0001-7230-3834 Ganchimeg BayarsaikhanIdris Lab, The Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA, USA.ORCID 0000-0003-3567-3726 Stephanie R WeldonBatista Lab, The Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA, USA.ORCID 0000-0001-5384-9946 Sven KratochvilBatista Lab, The Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA, USA.ORCID 0000-0002-0446-2371 Thavaleak PrumBatista Lab, The Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA, USA.ORCID 0009-0004-6973-5053 Ali A AlbowaideyBatista Lab, The Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA, USA.ORCID 0009-0000-2190-0620 Ye-Ji KimBatista Lab, The Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA, USA.ORCID 0000-0001-7155-9635 Jordan R Ellis-PughBatista Lab, The Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA, USA.ORCID 0009-0000-4155-3566 Quynh Anh PhanBatista Lab, The Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA, USA.ORCID 0000-0003-2199-262X Jennifer SuurbaarIdris Lab, The Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA, USA.ORCID 0000-0002-2683-9918 Robert Sifa OnjikoIdris Lab, The Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA, USA.ORCID 0009-0003-0721-1302 Gordon A DaleBatista Lab, The Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA, USA.ORCID 0000-0002-4995-6017 Haotian LeiResearch Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD, USA.ORCID 0000-0002-4882-0249 Nicholas C MoranoAaron Diamond AIDS Research Center and Department of Biochemistry, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.ORCID 0000-0002-8129-4033 Lawrence ShapiroAaron Diamond AIDS Research Center and Department of Biochemistry, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.ORCID 0000-0001-9943-8819 Usha NairBatista Lab, The Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA, USA.ORCID 0000-0002-1927-6889 Fidel ZavalaDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.ORCID 0000-0002-1414-6196 Facundo D BatistaBatista Lab, The Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA, USA.ORCID 0000-0002-1130-9463 Funding
Defining functional humoral correlates of immunity to guide vaccine designR01AI151178 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI BATISTA, FACUNDO DAMIAN · 2021 to 2025
$4.0MAccelerating Malaria Vaccines with a Custom Preclinical Humanized Mouse Model PlatformR01AI168114 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Facundo Damian Batista · 2022 to 2026
$3.5MNational Institute of Allergy and Infectious Diseases R01 AI151178National Institute of Allergy and Infectious Diseases R01 AI168114National Research Foundation of Korea 2021R1A6A3A14044219NCI NIH HHS 75N9101900024NCI NIH HHS 75N91019F00135NIAID NIH HHS R01 AI151178NIAID NIH HHS R01 AI168114NIH HHSRagon Institute of Mass General Brigham, MIT and Harvard
6 · The paper itselfAbstract
The first approval of malaria vaccines RTS,S/AS01 and R21/Matrix M marked a major milestone. Both vaccines present a portion of the Plasmodium falciparum circumsporozoite protein (PfCSP) containing an immunodominant major repeat region, which may limit breadth to other protective epitopes, limiting efficacy and durability. Using B cell receptor (BCR) knock-in mice, we found that the R21-included PfCSP epitope elicited robust B cell responses to the immunodominant major repeats but not to other highly protective epitopes, the minor repeat and junction. We then defined a minimal peptide capable of eliciting minor repeat-specific B cell responses and generating highly protective antibodies (Abs). We characterized these Abs bioinformatically and structurally to identify protective traits, which informed the design of variant Abs with improved affinity. Finally, we demonstrated that vaccination combining the R21-included PfCSP epitope, the minimal minor repeat peptide, and a junctional region immunogen elicited balanced B cell and Ab responses, enhancing protection in vivo. Broadening responses through immunofocusing may overcome immunogenic gaps in current malaria vaccines.
Indexed as
Malaria, FalciparumMalaria VaccinesPlasmodium falciparumProtozoan ProteinsAnimalsAntibodies, ProtozoanB-LymphocytesEpitopesEpitopes, B-LymphocyteFemaleMiceProtein Subunit VaccinesVaccines, SubunitAntibodies, Protozoancircumsporozoite protein, ProtozoanEpitopesEpitopes, B-LymphocyteMalaria VaccinesProtein Subunit VaccinesProtozoan ProteinsVaccines, Subunit
Identifiers
PMID42565808
PMCPMC13450000
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