Fluorescent cAMP Analogs: Enzymatic Synthesis, Unexpected Photophysical Behavior and Protein Kinase A Recognition.

Deyuan Cong, Victor Dubois, Jamie Y Lam, Yitzhak Tor

Abstract read

In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Deyuan CongDepartment of Chemistry, University of California San Diego, La Jolla, California, USA.

Victor DuboisDepartment of Chemistry, University of California San Diego, La Jolla, California, USA.ORCID https://orcid.org/0000-0001-9888-5713

Jamie Y LamDepartment of Chemistry, University of California San Diego, La Jolla, California, USA.

Yitzhak TorDepartment of Chemistry, University of California San Diego, La Jolla, California, USA.ORCID https://orcid.org/0000-0003-3726-7799

Funding

Fluorescent nucleosides, nucleotides and oligonucleotidesR35GM139407 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI YITZHAK TOR · 2021 to 2026

$2.5M

600 MHz NMR spectrometer with 1.7mm micro-cryoprobeS10OD032266 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DUGGAN, BRENDAN MICHAEL · 2023 to 2023

$1.8M

NIGMS NIH HHS R35 GM139407NIH HHS R35 GM 139407NIH HHS S10 OD032266

6 · The paper itself

Abstract

Cyclic adenosine monophosphate (cAMP) is a second messenger, regulating critical physiological processes. We report the enzymatic synthesis, unique photophysical features, and biological activity of novel emissive cAMP analogs (c

Indexed as

Cyclic AMPCyclic AMP-Dependent Protein KinasesFluorescent DyesAdenylyl CyclasesSpectrometry, FluorescenceAdenylyl CyclasesCyclic AMPCyclic AMP-Dependent Protein KinasesFluorescent Dyescyclic adenosine monophosphateemissive nucleosidesenzyme kineticsfluorescenceprotein kinase A

Identifiers

PMID42565734

DOI10.1002/anie.6334998

PMCPMC13638118

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.