Evidence map›Paper›PMID 42565660›Full record

ArticleTranslational vision science & technology2026

Quantitative Ciliary Body Imaging Using Image-Registered Swept-Source AS-OCT and Ultrasound Biomicroscopy.

Michie Namba, Anna Heur, Lucas L Humayun, Alexander Ko, Galo Apolo, Alex S Huang, Qifa Zhou, Benjamin Y Xu

Abstract read
In one paragraph

Article in Translational vision science & technology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Michie NambaRoski Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Anna HeurAlbany Medical College, Albany, NY, USA.
Lucas L HumayunRoski Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Alexander KoRoski Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Galo ApoloRoski Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Alex S HuangHamilton Glaucoma Center, Department of Ophthalmology, Shiley Eye Institute, University of California San Diego, La Jolla, CA, USA.
Qifa ZhouRoski Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Benjamin Y XuRoski Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Funding

Ophthalmic Therapeutics Engineering CoreP30EY029220 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Mahnaz Shahidi · 2018 to 2026
$6.5M
Clinical Evaluation and Risk Stratification of Angle Closure Disease Using Quantitative OCTR01EY035677 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Benjamin Y. Xu · 2024 to 2026
$1.4M
NEI NIH HHS P30 EY029220NEI NIH HHS R01 EY035677
6 · The paper itself

Abstract

Purpose: The purpose of this study was to evaluate inter- and intra-device agreement of ciliary body (CB) biometric parameters measured by image-registered swept-source anterior segment optical coherence tomography (AS-OCT; ANTERION, Heidelberg Engineering, Heidelberg, Germany) and ultrasound biomicroscopy (UBM; Insight 100, ArcScan). Methods: Patients undergoing anterior segment imaging were prospectively enrolled. Horizontal scans were acquired under standardized illumination. One eye per participant was randomly selected for analysis. Maximum ciliary muscle thickness (CMTMAX), maximum CB thickness (CBTMAX), sulcus-to-sulcus (STS) distance, and scleral spur-to-scleral spur (SSS) distance were manually measured. Eyes with pupillary diameter differences ≥15% were excluded. Inter- and intra-device agreement were assessed using intraclass correlation coefficients (ICCs), linear regression, and Bland-Altman analysis. Results: Seventy-eight eyes from 78 subjects (mean age = 61.9 ± 12.6 years) were analyzed. Inter-device agreement was good to excellent (ICC = 0.60-0.85). Mean absolute inter-device differences were 57.6 ± 36.6 µm for CBTMAX, 40.6 ± 44.7 µm for CMTMAX, 0.28 ± 0.23 mm for SSS, and 0.18 ± 0.16 mm for STS; corresponding mean absolute relative inter-device differences were 4.8% for CBTMAX, 5.9% for CMTMAX, 1.5% for SSS, and 2.5% for STS. Greater baseline CBTMAX was the only factor consistently associated with inter-device differences in CBTMAX or CMTMAX (P < 0.001). Intra-device repeatability was excellent across all parameters for both systems (ICC = 0.78-0.90 for ANTERION and 0.80-0.94 for Insight). Conclusions: Image-registered AS-OCT and UBM provided largely concordant and highly repeatable CB measurements, although systematic inter-device differences across the two modalities suggest they cannot be considered fully interchangeable. Translational Relevance: Modern image-registered swept-source AS-OCT provides a viable, non-contact alternative to UBM for quantitative CB assessment.

Indexed as

Ciliary BodyMicroscopy, AcousticTomography, Optical CoherenceAdultAgedBiometryFemaleHumansMaleMiddle AgedProspective StudiesReproducibility of Results

Identifiers

PMID42565660
PMCPMC13456063

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.