ArticlemSystems2026
Metabolic rewiring of bacterial subpopulations governs polymyxin responses in
Mei-Ling Han, Zhi Ying Kho, Xingjian Wang, Jinxin Zhao, Ben Finnin, Yan Zhu, Christopher K Barlow, Darren J Creek, Tony Velkov, Mohammad A K Azad and 1 more
Abstract read
In one paragraphArticle in mSystems, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
11 authors.
Mei-Ling HanInfection Program and Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.ORCID 0000-0002-0861-2437 Zhi Ying KhoInfection Program and Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Xingjian WangInfection Program and Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Jinxin ZhaoInfection Program and Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Ben FinninCell Therapy Pty Ltd, Melbourne, Victoria, Australia.
Yan ZhuSystems Biology Centre, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.ORCID 0000-0001-7342-3782 Christopher K BarlowMonash Proteomics and Metabolomics Platform, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Darren J CreekMonash Proteomics and Metabolomics Platform, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.ORCID 0000-0001-7497-7082 Tony VelkovDepartment of Pharmacology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Mohammad A K AzadInfection Program and Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Jian LiInfection Program and Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.ORCID 0000-0001-7953-8230 Funding
Targeting the Urgent Need for New Antibiotics against Gram-negative ‘Superbugs’R01AI132154 · NIAID · MONASH UNIVERSITY · PI LI, JIAN, VELKOV, TONY · 2017 to 2021
$4.3MDepartment of Education and Training | Australian Research Council (ARC) DP250102726, DE230100356Department of Education and Training | Australian Research Council (ARC) FT220100564Department of Education and Training | Australian Research Council (ARC) IM230100534National Health and Medical Research Council APP2025937National Institute of Allergy and Infectious Diseases R01 AI132154NIAID NIH HHS R01 AI132154
6 · The paper itselfAbstract
Polymyxins are often last-resort antibiotics against high-priority Gram-negative pathogens, particularly
Indexed as
Acinetobacter baumanniiAnti-Bacterial AgentsPolymyxinsArginineFlow CytometryMetabolic ReprogrammingAnti-Bacterial AgentsArgininePolymyxinsAcinetobacter baumanniiarginine metabolismcell-sortingheteroresistancemetabolomicsPI stainingpolymyxins
Identifiers
PMID42565598
PMCPMC13595966
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