ArticleZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences2026
[Single
Article in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesNon-alcoholic fatty liver disease (NAFLD) is a globally prevalent chronic liver disease, and its progression is closely associated with Kupffer cells (KCs). This study aims to characterize C-X-C motif chemokine ligand 9꞉secreted phosphoprotein 1 (CS) polarization in KCs and investigate its intercellular communication with endothelial cells (ECs) in NAFLD.
methodsSingle-cell RNA sequencing data of liver tissues from 3 NAFLD mice and 3 control mice were obtained from the Gene Expression Omnibus (GEO) dataset GSE129516. Seurat was used for data integration, quality control, clustering, and annotation. KCs and ECs were divided into subgroups, followed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses. A mouse liver single-cell dataset (GSE270583) was further included for cross-validation of CS polarization. CellChat was used to infer intercellular communication networks between KC and EC subgroups. Twenty male C57BL/6J mice were assigned to a control group (
resultsA total of 29 cell clusters belonging to 8 cell types were identified. Compared with the control group, the proportion of KCs was increased and the proportion of ECs was decreased in the NAFLD group. Under M1/M2 and CS polarization frameworks, subgroups including CD80
conclusionsKCs in NAFLD exhibit characteristics of CS polarization, with increased proportions of SPP1
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