Evidence map›Paper›PMID 42565568›Full record

ArticleZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences2026

Targeting

Zili Lin, Hao Luo, Xiangyao Li, Wei Luo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Zili LinDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha 410008. woslinzili@163.com.
Hao LuoDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha 410008. drluohao@163.com.
Xiangyao LiDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha 410008.
Wei LuoDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha 410008. luoweixy@csu.edu.cn.

Funding

the Health High-Level Talent Scientific Research Project of Hunan Province R2023175the Science and Technology Innovation Plan Project of Hunan Province 2023SK2023
6 · The paper itself

Abstract

objectivesOsteosarcoma (OS) is a malignant bone tumor that predominantly affects adolescents. Due to its early metastatic tendency and chemoresistance, long-term survival rates in patients have not shown significant improvement over time, highlighting the urgent need for novel molecular targets and therapeutic strategies. Ferroptosis, a form of programmed cell death driven by iron-dependent lipid peroxidation, offers a promising avenue for overcoming drug-resistant tumors. ATP-binding cassette subfamily B member 6 (

methodsHuman OS cell lines (HOS and 143B) and human bone marrow mesenchymal stem cells (BMSCs) were used as research subjects. Stable

resultsBoth messenger RNA (mRNA) and protein levels of

conclusionsThis study systematically uncovers, for the first time, the oncogenic role and prognostic value of

Indexed as

ATP-Binding Cassette TransportersBone NeoplasmsFerroptosisHypoxia-Inducible Factor 1, alpha SubunitOsteosarcomaPhospholipid Hydroperoxide Glutathione PeroxidaseAnimalsCell Line, TumorFemaleHumansMiceMice, NudeSignal TransductionABCB6 protein, humanATP-Binding Cassette TransportersHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitPhospholipid Hydroperoxide Glutathione PeroxidaseABCB6ferroptosisGPX4HIF1Aosteosarcoma

Identifiers

PMID42565568
PMCPMC13407292

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.