Evidence map›Paper›PMID 42565524›Full record

ArticleThe Journal of comparative neurology2026

Brain-Wide Mapping and Synaptic Localization of C1QL3 Using a Novel Epitope-Tagged Knock-In Mouse.

William P Armstrong, James M Salvatore, Matthew J Sticco, Keaven Caro, J Wesley Maddox, Angie Huang, Brenna C McAllister, Christopher B O'Connell, Siu-Pok Yee, Amy Lee and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of comparative neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

William P ArmstrongDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, USA.
James M SalvatoreDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, USA.
Matthew J SticcoDepartment of Neuroscience, University of Connecticut Health, Farmington, Connecticut, USA.
Keaven CaroDepartment of Neuroscience, University of Connecticut Health, Farmington, Connecticut, USA.
J Wesley MaddoxDepartment of Neuroscience, University of Texas at Austin, Austin, Texas, USA.
Angie HuangDepartment of Neuroscience, University of Texas at Austin, Austin, Texas, USA.
Brenna C McAllisterDepartment of Neuroscience, University of Connecticut Health, Farmington, Connecticut, USA.
Christopher B O'ConnellAdvanced Light Microscopy Facility, Center for Open Research Resources and Equipment, University of Connecticut, Storrs, Connecticut, USA.
Siu-Pok YeeCenter for Mouse Genome Modification, UConn Health, Farmington, Connecticut, USA.
Amy LeeDepartment of Neuroscience, University of Texas at Austin, Austin, Texas, USA.
Susanne ResslDepartment of Neuroscience, University of Texas at Austin, Austin, Texas, USA.
David C MartinelliDepartment of Neuroscience, University of Connecticut Health, Farmington, Connecticut, USA.
Alexander C JacksonDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, USA.

Funding

Inhibitory Cell Types and Circuits in the Lateral HypothalamusR01MH112739 · NIMH · UNIVERSITY OF CONNECTICUT STORRS · PI Alexander Choi Jackson · 2017 to 2026
$5.1M
Calcium channels in retinal photoreceptorsR01EY026817 · NEI · UNIVERSITY OF TEXAS AT AUSTIN · PI LEE, AMY · 2017 to 2025
$4.4M
A novel trans-synaptic adhesion complex as a regulator of hypocretin/orexin control of arousalR01NS131664 · NINDS · UNIVERSITY OF CONNECTICUT STORRS · PI Alexander Choi Jackson, David Christopher Martinelli · 2024 to 2026
$1.9M
STED Super Resolution Microscope for a Core FacilityS10OD023618 · OD · UNIVERSITY OF CONNECTICUT STORRS · PI O'CONNELL, CHRISTOPHER B · 2018 to 2018
$1000k
Leica TCS SP8 FSU AOBS 405 UV Spectral Confocal MicroscopeS10OD016435 · OD · UNIVERSITY OF CONNECTICUT STORRS · PI NISHIYAMA, AKIKO · 2014 to 2014
$456k
Determination of the subcellular localization of adhesion G protein-coupled receptor B3 (ADGRB3) and its locations of interaction with secreted C1Q-like ligandsR03DC019290 · NIDCD · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI MARTINELLI, DAVID CHRISTOPHER · 2020 to 2020
$164k
Illuminating the function of CACNA2D4 in inherited retinal dystrophiesR03TR005086 · NCATS · UNIVERSITY OF TEXAS AT AUSTIN · PI LEE, AMY · 2024 to 2024
$159k
The biophysical basis of the ADGRB3 extra-cellular interaction network.R03TR004494 · NCATS · UNIVERSITY OF TEXAS AT AUSTIN · PI RESSL, SUSANNE · 2023 to 2023
$152k
The role of presynaptic C1QL3 in a hypothalamic arousal circuitF31HL165896 · NHLBI · UNIVERSITY OF CONNECTICUT STORRS · PI ARMSTRONG, WILLIAM PATRICK · 2022 to 2024
$143k
NCATS NIH HHS R03 TR004494NCATS NIH HHS R03 TR005086NEI NIH HHS R01 EY026817NHLBI NIH HHS F31 HL165896NIDCD NIH HHS R03 DC019290NIH HHS F31HL165896NIH HHS R01EY026817NIH HHS R01MH112739NIH HHS R01NS131664NIH HHS R03DC019290NIH HHS R03TR004494NIH HHS R03TR005086NIH HHS S10 OD016435NIH HHS S10OD016435NIH HHS S10 OD023618NIH HHS S10OD023618NIMH NIH HHS R01 MH112739NINDS NIH HHS R01 NS131664
6 · The paper itself

Abstract

Synapse formation and function are coordinated spatially and temporally by a host of synaptic proteins that regulate neuronal signaling, synapse specificity, and plasticity, many of which are implicated in neuropsychiatric disorders. Many members of the C1q/TNF superfamily function as synaptic organizers, shaping synapse assembly and maintenance. Among them, C1QL3 plays a putative role in trans-synaptic adhesion and modulation of synaptic strength, but the lack of a reliable antibody to detect it has severely limited the ability to map its endogenous localization and study its biochemical properties. Here, we present a novel epitope-tagged knock-in mouse line (C1ql3

Indexed as

BrainBrain MappingComplement C1qNerve Tissue ProteinsSynapsesAnimalsEpitopesGene Knock-In TechniquesMiceMice, Inbred C57BLMice, TransgenicComplement C1qEpitopesNerve Tissue ProteinsC1QL3CTRP13epitope tagknock‐in mouselight‐sheet imagingsuper‐resolution microscopysynapsesynaptic adhesion molecule

Identifiers

PMID42565524
PMCPMC13449632

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.