ArticleLab on a chip2026
EZ-SPOTs: a simple, low-cost, high-throughput liquid handling platform applied to antimicrobial susceptibility testing of clinical isolates.
Article in Lab on a chip, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- A digital droplet microarray for measuring tolerance to antibiotics.bioRxiv : the preprint server for biology · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
High-performance liquid handling is essential for a wide range of experiments. Previously, we introduced the Surface Patterned Omniphobic Tiles (SPOTs) platform, which enables manipulation of hundreds to thousands of independent experiments without costly equipment or excessive consumable expenses. However, the SPOTs platform uses a custom coating that requires a chemical synthesis step. This coating is also easily damaged by handling and requires careful manipulation, making it challenging to transport and interface the platform with existing well plates. To overcome these challenges, here we introduce the EZ-SPOTs platform which can be created in an hour with common fabrication tools and three components: glass, a phobic coating, and plastic. EZ-SPOTs preserve many of the SPOTs platform's strengths including ease of use, the ability to handle a wide range of volumes, and scalability, but by adopting a robust, abrasion-resistant coating, EZ-SPOTs devices can be reused. Additionally, this improved robustness enables the platform to address the "chip-to-lab" obstacle by directly interfacing with 96-well plates. Here, we describe the fabrication of EZ-SPOTs and showcase how devices can be reused to test many isolates for antimicrobial susceptibility. These results quantitatively match current gold-standard assays, and the increased throughput provides substantially more information than standard approaches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.