Evidence map›Paper›PMID 42565258›Full record

ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2026

Increased exertion variability is linked to disruptions in effort assessment in multiple sclerosis.

Michael H Dryzer, Bardia Nourbakhsh, Jennifer Keller, Vikram S Chib

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Michael H DryzerDepartment of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0009-0009-0677-342X
Bardia NourbakhshDepartment of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jennifer KellerKennedy Krieger Institute, Baltimore, MD, USA.
Vikram S ChibKennedy Krieger Institute, Baltimore, MD, USA.

Funding

Behavioral and Neural Representations of Subjective Effort CostR01MH119086 · NIMH · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Vikram S Chib · 2019 to 2026
$3.7M
Subjective Valuation of Physical Effort in Health and DiseaseR01HD097619 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI CHIB, VIKRAM S · 2019 to 2023
$2.0M
NICHD NIH HHS R01 HD097619NIMH NIH HHS R01 MH119086
6 · The paper itself

Abstract

backgroundIndividuals with multiple sclerosis (MS) often report fatigue and motor impairments, which may affect how accurately they assess physical exertion. Recent work with healthy individuals suggests that motor variability can distort judgments of exertion (i.e. feelings of effort); however, this relationship has not been explored in individuals with MS.

objectiveTo determine how variability in physical exertion affects subjective effort assessment in individuals with MS compared with healthy participants.

methodsIndividuals with MS and age-matched healthy controls exerted varying levels of physical exertion and retrospectively assessed the feelings of effort associated with their exertion. Hierarchical linear models were used to compare motor performance and effort assessment metrics between cohorts.

resultsIn total, 29 patients with MS and 22 healthy controls were included. Individuals with MS exhibited increased exertion variability compared with healthy participants

Indexed as

effortexertionmotor performanceMultiple sclerosis

Identifiers

PMID42565258
PMCPMC13466927

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.