Evidence map›Paper›PMID 42565253›Full record

ArticleMicrobial biotechnology2026

Conjunctival Sac-Derived Lactobacillus mucosae MM-1 Metabolite Indole-3-Lactic Acid Attenuates Lens-Induced Myopia in Mice via AHR Activation and TGF-β/Smad Inhibition.

Yanqing Li, Qiuyu Wu, Xilong Zhang, Luchuan Liu, Leiping Ding, Jingjing Xu, Chiwen Cheng, Yangyang Peng, Kang Yu, Wen Yao and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbial biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yanqing LiDepartment of Ophthalmic Center, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China.ORCID https://orcid.org/0000-0002-5027-2886
Qiuyu WuQueen Mary School, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China.ORCID https://orcid.org/0009-0005-3455-4794
Xilong ZhangQueen Mary School, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China.ORCID https://orcid.org/0009-0009-5586-7801
Luchuan LiuQueen Mary School, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China.ORCID https://orcid.org/0009-0004-5844-6774
Leiping DingQueen Mary School, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China.ORCID https://orcid.org/0009-0009-0675-2194
Jingjing XuDepartment of Ophthalmic Center, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China.ORCID https://orcid.org/0000-0001-9245-4621
Chiwen ChengDepartment of Ophthalmic Center, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China.ORCID https://orcid.org/0000-0002-9882-0140
Yangyang PengDepartment of Ophthalmic Center, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China.ORCID https://orcid.org/0009-0001-7146-7877
Kang YuDepartment of Ophthalmic Center, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China.ORCID https://orcid.org/0009-0000-5124-3000
Wen YaoDepartment of Ophthalmic Center, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China.ORCID https://orcid.org/0009-0003-8021-5545
Yijie PiDepartment of Ophthalmic Center, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China.ORCID https://orcid.org/0009-0008-9894-4072
Jiale LiDepartment of Ophthalmic Center, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China.ORCID https://orcid.org/0009-0009-8120-4075
Di WuDepartment of Ophthalmic Center, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China.ORCID https://orcid.org/0009-0002-6031-4127
Jing WeiSchool of Pharmacy, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China.ORCID https://orcid.org/0009-0004-1963-3569
Yifeng YuDepartment of Ophthalmic Center, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China.ORCID https://orcid.org/0000-0002-6598-2274
Tingtao ChenDepartment of Ophthalmic Center, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China.ORCID https://orcid.org/0000-0002-0506-8536

Funding

Graduate Innovation Special Fund of Jiangxi Province YC2024-B072
6 · The paper itself

Abstract

Emerging research has revealed a diverse microbiota in the high myopia (HM) conjunctival sac, highlighting the therapeutic potential of modulating this community to influence disease outcomes. However, current research on targeted modulation of this microbiota for myopia intervention lacks in-depth investigation and definitive conclusions regarding its efficacy and underlying mechanisms. In this study, high-throughput sequencing and culturomics were first used to screen the conjunctival sac microbiota of healthy people, identifying Lactobacillus mucosae MM-1 as a potential probiotic for myopia control. Then, animal studies further confirmed that L. mucosae MM-1 significantly attenuated lens-induced myopia, improved COL1A1 expression and scleral integrity and elevated Lactobacillus abundance. Furthermore, untargeted metabolomics analysis suggested that indole-3-lactic acid (ILA) may be a key substance for L. mucosae MM-1 to exert its effects for myopia control. Mechanistically, pharmacological ILA supplementation supports the involvement of AHR in TGF-β/Smad pathway inhibition, accompanied by altered COL1A1 and α-SMA expression and attenuation of lens-induced myopia in mice. Therefore, these findings suggest that L. mucosae MM-1 may attenuate lens-induced myopia in mice, at least in part, through ILA-mediated regulation of the TGF-β/Smad pathway, and offer a theoretical foundation for future therapeutic strategies based on conjunctival sac microbiome manipulation.

Indexed as

ConjunctivaIndolesLactobacillusMyopiaProbioticsReceptors, Aryl HydrocarbonSmad ProteinsTransforming Growth Factor betaAnimalsCollagen Type IDisease Models, AnimalHumansMaleMiceMicrobiotaSignal TransductionCollagen Type IIndolesReceptors, Aryl HydrocarbonSmad ProteinsTransforming Growth Factor betaAHRhigh myopiaIndole‐3‐lactic acidLactobacillus mucosaeTGF‐β/Smad signalling pathway

Identifiers

PMID42565253
PMCPMC13449032

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.