Evidence map›Paper›PMID 42565246›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Dorsal raphe tau pathology disrupts sleep-wake orchestration and sleep architecture in a sex-specific manner.

Louis J Kolling, Ruixiang Wang, Gabriel S Gaudencio, Jamie S Fishbeyn, Thomas D James, Suzanne M Mason, Riley O McCoy, Zhimin Song, Ian Pascal McConnell, Kylie Ziemke and 5 more

Abstract read
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Louis J KollingDepartment of Neuroscience and Pharmacology, University of Iowa, Iowa City, Iowa, USA.ORCID https://orcid.org/0000-0003-0597-0199
Ruixiang WangDepartment of Neuroscience and Pharmacology, University of Iowa, Iowa City, Iowa, USA.
Gabriel S GaudencioDepartment of Neuroscience and Pharmacology, University of Iowa, Iowa City, Iowa, USA.
Jamie S FishbeynDepartment of Cellular and Systems Pharmacology, University of Florida, Gainesville, Florida, USA.
Thomas D JamesDepartment of Neuroscience and Pharmacology, University of Iowa, Iowa City, Iowa, USA.
Suzanne M MasonDepartment of Neuroscience and Pharmacology, University of Iowa, Iowa City, Iowa, USA.
Riley O McCoyDepartment of Neuroscience and Pharmacology, University of Iowa, Iowa City, Iowa, USA.
Zhimin SongDepartment of Neuroscience and Pharmacology, University of Iowa, Iowa City, Iowa, USA.
Ian Pascal McConnellDepartment of Neuroscience and Pharmacology, University of Iowa, Iowa City, Iowa, USA.
Kylie ZiemkeDepartment of Cellular and Systems Pharmacology, University of Florida, Gainesville, Florida, USA.
Kasia M JanikDepartment of Neuroscience and Pharmacology, University of Iowa, Iowa City, Iowa, USA.
Yu XuDepartment of Neuroscience and Pharmacology, University of Iowa, Iowa City, Iowa, USA.
Gabrielle Bierlein-De La RosaDepartment of Neuroscience and Pharmacology, University of Iowa, Iowa City, Iowa, USA.
Shafa IsmailDepartment of Neuroscience and Pharmacology, University of Iowa, Iowa City, Iowa, USA.
Catherine Anne MarcinkiewczDepartment of Neuroscience and Pharmacology, University of Iowa, Iowa City, Iowa, USA.ORCID https://orcid.org/0000-0001-7161-7815

Funding

Sleep and affective disturbances in the etiology of Alzheimer's diseaseR01AG070841 · NIA · UNIVERSITY OF IOWA · PI MARCINKIEWCZ, CATHERINE ANNE · 2021 to 2025
$2.8M
Reversal of Tau Pathology to Rescue Serotonergic Function in Early Alzheimer’s DiseaseF32AG084196 · NIA · UNIVERSITY OF IOWA · PI KOLLING, LOUIS · 2024 to 2024
$77k
Alzheimer's Association and the Michael J. Fox Foundation for Parkinson's Research: 26BFDN-1576146AIowa Neuroscience Institute Research Program of Excellence (RPOE)NIA NIH HHS F32 AG084196NIA NIH HHS F32AG084196-01NIA NIH HHS R01 AG070841Pappajohn Biomedical InstituteUniversity of Iowa
6 · The paper itself

Abstract

introductionSleep disturbances are frequent symptoms of Alzheimer's disease (AD), mirrored by early pathology in the dorsal raphe nucleus (DRN). Whether early DRN pathology can drive sleep disturbances, and the relative contributions of serotonin (5-HT) and sex, has not been directly tested.

methodsWe isolate tau pathology to whole DRN (DRN

resultsDRN DISCUSSION: Tau-mediated sleep dysfunction may be driven by various cellular subtypes of the DRN, are primarily sexually divergent, and may resultant in changes in 5-HT activity and relative spectral brain wave contributions.

Indexed as

Dorsal Raphe NucleusSex CharacteristicsSleepSleep Wake DisordersTauopathiestau ProteinsAlzheimer DiseaseAnimalsElectroencephalographyFemaleMaleMiceSerotoninWakefulnessSerotonintau ProteinsAlzheimer's diseasedorsal raphe nucleuselectroencephalogramsleeptau

Identifiers

PMID42565246
PMCPMC13449038

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.