ArticleClinical and experimental vaccine research2026
The impact of influenza vaccination on the clinical severity of influenza among children aged 6 months to 6 years living in the community: a prospective cohort study.
Article in Clinical and experimental vaccine research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
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Abstract
Purpose: Evidence on whether influenza vaccination reduces disease severity in children with breakthrough infections in community settings is limited. Materials and Methods: This prospective study enrolled 388 children (aged 6 months-6 years) diagnosed with influenza at a community health center in Shenzhen from May 2024 to October 2025. Participants were grouped by vaccination status within the prior year: vaccinated (n=196) and unvaccinated (n=192). Clinical characteristics, healthcare utilization, and outcomes were compared. Results: Vaccinated children showed significantly lower peak body temperature (38.81°C±0.58°C vs. 39.03°C±0.64°C), shorter fever duration (2.01±1.21 days vs. 2.45±1.55 days), and fewer symptoms like myalgia and gastrointestinal issues (all p<0.01). They also had fewer outpatient visits, lower outpatient costs, and markedly reduced rates of hospitalization (4.1% vs. 21.9%) and antibiotic use (5.6% vs. 15.1%) (all p<0.05). Conclusion: Influenza vaccination could mitigate symptoms, reduce hospitalization and antibiotic use, and lessen the healthcare burden from breakthrough infections.
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