Evidence map›Paper›PMID 42565131›Full record

ArticleiScience2026

Early immune dysregulation in

Riti Sharan, Yi Zou, Zhao Lai, Korri Weldon, Todd Bradley, Xi Luo, Hulin Wu, Shabaana A Khader, Deepak Kaushal

Abstract read
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Riti SharanSouthwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78227, USA.
Yi ZouGreehey Children's Cancer Research Institute, UTHealth San Antonio, San Antonio, TX 78229, USA.
Zhao LaiGreehey Children's Cancer Research Institute, UTHealth San Antonio, San Antonio, TX 78229, USA.
Korri WeldonGreehey Children's Cancer Research Institute, UTHealth San Antonio, San Antonio, TX 78229, USA.
Todd BradleyGenomic Medicine Center, Children's Mercy Research Institute, Children's Mercy Kansas City, Kansas City, MO 64108, USA.
Xi LuoUTHealth Houston School of Public Health, Houston, TX 77030, USA.
Hulin WuUTHealth Houston School of Public Health, Houston, TX 77030, USA.
Shabaana A KhaderBernard and Betty Roizman Professor and Chair, University of Chicago Department of Microbiology and Immunology, Chicago, IL 60637, USA.
Deepak KaushalSouthwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78227, USA.

Funding

TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Lei Zheng · 1991 to 2026
$59.1M
Viral Testing CoreU42OD010442 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Deepak Kaushal · 2012 to 2026
$35.6M
Texas Developmental Center for AIDS ResearchP30AI161943 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI GIORDANO, THOMAS P · 2021 to 2025
$8.3M
Interdisciplinary NexGen TB research Advancement Center (IN-TRAC)P30AI168439 · NIAID · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI JOANNE TURNER · 2022 to 2026
$6.9M
Perturbation of antigen-specific T cell responses in latent TB/SIV co-infectionR01AI111943 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI KAUSHAL, DEEPAK, RENGARAJAN, JYOTHI · 2015 to 2019
$3.9M
Impact of concurrent HIV and latent TB therapies on Mtb-specific immune function-Diversity SupplementR01AI123047 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI KAUSHAL, DEEPAK, RENGARAJAN, JYOTHI · 2017 to 2020
$3.9M
Enhancing pulmonary immune reconstitution and limiting viral persistence with IL-21 therapy in Mtb/SIV co-infectionR01AI194937 · NIAID · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Riti Sharan · 2026 to 2026
$927k
Single cell trancriptomics to identify LTBI reactivation markers in TB/HIV co-infectionR21AI170148 · NIAID · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI SHARAN, RITI · 2022 to 2023
$800k
Effect of IL-21 treatment concurrent to ART and 3HP in Mtb/SIV co-infectionR56AI184089 · NIAID · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI SHARAN, RITI · 2024 to 2024
$719k
Illumina NovaSeq 6000 Sequencing SystemS10OD030311 · OD · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI LAI, ZHAO · 2021 to 2021
$600k
Characterizing IL-22 driven chronic immune activation in HIV/TB co-pandemicK01OD031898 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI SHARAN, RITI · 2021 to 2023
$567k
Significant upgrade and expansion of the Southwest National Primate Research Center Pathology UnitS10OD028732 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI KAUSHAL, DEEPAK · 2020 to 2020
$489k
NCI NIH HHS P30 CA054174NIAID NIH HHS P30 AI161943NIAID NIH HHS P30 AI168439NIAID NIH HHS R01 AI111943NIAID NIH HHS R01 AI123047NIAID NIH HHS R01 AI194937NIAID NIH HHS R21 AI170148NIAID NIH HHS R56 AI184089NIH HHS K01 OD031898NIH HHS S10 OD028732NIH HHS S10 OD030311NIH HHS U42 OD010442
6 · The paper itself

Abstract

Using single-cell transcriptomics of bronchoalveolar lavage cells from

Indexed as

HIVLTBINHPscRNA-seqTB/SIVType I IFN

Identifiers

PMID42565131
PMCPMC13446293

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.