Evidence map›Paper›PMID 42565110›Full record

ArticleFrontiers in immunology2026

Recombinant rat heat shock protein 70 (rrHSP70) may promote remyelination by regulating microglia/macrophages and oligodendrocytes in a toxin-induced demyelination animal model.

Jian Song, Jiayan Wang, Yuanzhi Li, Hui Wang, Mei Li, Fei Huang, Xiaoming Zhang, Ding Wan, Jiahao Ye, Keyu Zhou and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Jian Song *Ningxia Key Laboratory of Cerebrocranial Diseases, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia, China.
Jiayan Wang *Ningxia Key Laboratory of Cerebrocranial Diseases, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia, China.
Yuanzhi LiNingxia Key Laboratory of Cerebrocranial Diseases, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia, China.
Hui WangNingxia Key Laboratory of Cerebrocranial Diseases, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia, China.
Mei LiCollege of Traditional Chinese Medicine, Ningxia Key Laboratory of Cerebrocranial Diseases, Ningxia Medical University, Yinchuan, Ningxia, China.
Fei HuangEmergency Department of Ningxia Medical University General Hospital; Key Laboratory of Craniocerebral Diseases, Ningxia Medical University, Yinchuan, Ningxia, China.
Xiaoming ZhangCenter for Translational Neurodegeneration and Regenerative Therapy, Shanghai Tongji Hospital Affiliated to Tongji University School of Medicine, Shanghai, China.
Ding WanDepartment of Neurosurgery, General Hospital of Ningxia Medical University; Ningxia Key Laboratory of Cerebrocranial Diseases, Ningxia Medical University;, Yinchuan, Ningxia, China.
Jiahao YeSchool of Clinical Medicine, Ningxia Medical University, Yinchuan, Ningxia, China.
Keyu ZhouSchool of Clinical Medicine, Ningxia Medical University, Yinchuan, Ningxia, China.
Lu YangNingxia Key Laboratory of Cerebrocranial Diseases, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia, China.
Haining LiDepartment of Neurology, General Hospital of Ningxia Medical University, Ningxia Key Laboratory of Cerebrocranial Diseases, Ningxia Medical University;, Yinchuan, Ningxia, China.
Chun ZhangNingxia Key Laboratory of Cerebrocranial Diseases, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia, China.
Tao SunDepartment of Neurology, General Hospital of Ningxia Medical University, Ningxia Key Laboratory of Cerebrocranial Diseases, Ningxia Medical University;, Yinchuan, Ningxia, China.
Qiaofeng WanNingxia Key Laboratory of Cerebrocranial Diseases, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia, China.
Shaozhang HouNingxia Key Laboratory of Cerebrocranial Diseases, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia, China.
Changseng LengState Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Department of Thoracic Surgery, Guangdong Esophageal Cancer Institute, Sun Yat-sen University Cancer Center, Guangzhou, China.
Peng WangNingxia Key Laboratory of Cerebrocranial Diseases, Key Laboratory of Dryness Syndrome in Chinese Medicine, Ministry of Education, School of Basic MedicalSciences,Ningxia Medical University, Yinchuan, Ningxia, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heat shock protein 70 (HSP70) can assemble with other extracellular matrix proteins to form deoxycholate-insoluble aggregates in multiple sclerosis (MS) lesions, impairing oligodendrocyte (OLG) maturation and remyelination. However, soluble HSP70 supports myelination. HSP70 may also promote bone marrow-derived macrophages (BMDMs) toward classically and alternatively activated phenotypes, which may regulate OLG maturation. Given the roles of HSP70 in OLG maturation and in shaping microglial/BMDM phenotypes in MS lesions, we investigated how HSP70 in microglia/macrophages regulates OLG maturation in a toxin-induced demyelination model. Our results suggest that rrHSP70 may maintain HSP70 expression in microglia and BMDMs

Indexed as

Demyelinating DiseasesHSP70 Heat-Shock ProteinsMacrophagesMicrogliaOligodendrogliaRemyelinationAnimalsDisease Models, AnimalMultiple SclerosisPhagocytosisRatsRecombinant ProteinsHSP70 Heat-Shock ProteinsRecombinant Proteinsmultiple sclerosis (MS)oligodendrocytes (OLGs)phagocytosis of microglia and macrophagesrecombinant rat heat shock protein 70 (rrHSP70)remyelination

Identifiers

PMID42565110
PMCPMC13446012

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.