ArticleEuropean urology open science2026
Clinical Impact of Germline Pathogenic Variants in High-risk Prostate Cancer Treated with Radiotherapy.
Article in European urology open science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
13 authors.
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Abstract
Background: Pathogenic and likely pathogenic (P/LP) germline variants in cancer susceptibility genes (CSGs) are detected in 5-10% of patients with prostate cancer, but their clinical impact in high-risk disease remains unclear. Objective: This study aimed to assess the prevalence of P/LP variants in CSGs among patients with high-risk prostate cancer and their association with oncologic outcomes in patients treated with radiotherapy. Methods: We conducted a retrospective study of 600 men with high-risk prostate cancer. Germline DNA was analyzed using a 19-gene panel, and gene-level variant prevalence was compared with non-cancer control cohorts using Fisher's exact test. Time-to-event analyses were performed in the 390 patients treated with radiotherapy as primary curative intent. The primary endpoint was overall survival (OS), assessed by Kaplan-Meier and multivariable Cox regression. Secondary endpoints included biochemical recurrence, distant metastasis, prostate cancer-specific mortality (PCSM), and second primary malignancies, analyzed using cumulative incidence functions and Fine-Gray competing-risk models. Key findings and limitations: P/LP variants were identified in 8.0% of patients ( Conclusions and clinical implications: Germline P/LP variants are prevalent in high-risk prostate cancer and define gene-specific subgroups with distinct oncologic outcomes, supporting the role of germline genetic testing in risk stratification and treatment decision-making.
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