Evidence map›Paper›PMID 42565036›Full record

ArticleIJID regions2026

Host and pathogen factors modulate tuberculosis clinical severity independent of molecular bacterial burden: insights from a multicenter Ghanaian cohort.

Theophilus Afum, Prince Asare, Stephen Osei-Wusu, Ivy Naa Koshie Lamptey, Susan Darkwahene-Boateng, Britta S Meyer, Tobias L Lenz, Dorothy Yeboah-Manu

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Article in IJID regions, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Theophilus AfumNoguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Ghana.
Prince AsareNoguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Ghana.
Stephen Osei-WusuNoguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Ghana.
Ivy Naa Koshie LampteyNoguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Ghana.
Susan Darkwahene-BoatengNoguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Ghana.
Britta S MeyerResearch Unit for Evolutionary Immunogenomics, Department of Biology, University of Hamburg, Hamburg, Germany.
Tobias L LenzResearch Unit for Evolutionary Immunogenomics, Department of Biology, University of Hamburg, Hamburg, Germany.
Dorothy Yeboah-ManuNoguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Ghana.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Tuberculosis (TB) exhibits marked clinical heterogeneity, complicating prognosis, and disease management. Identifying reliable predictors of disease trajectory and severity could improve risk stratification. Methodology: We investigated determinants of TB severity in 727 sputum-positive individuals recruited from five health facilities in Ghana. Participants were classified as TB-only, TB-human immunodeficiency virus, or TB-diabetes mellitus. Disease severity was assessed using the Bandim TB score II. Bacterial burden was quantified using GeneXpert Results: Bacterial load differed modestly across comorbidity groups, but GeneXpert cycle threshold values showed no significant correlation with clinical severity (Spearman's ρ = -0.006, Conclusion: Host nutritional status, socio-demographic factors, and pathogen genotype were more consistently associated with TB severity than molecular bacterial burden alone, supporting a host-pathogen interaction framework to explain clinical heterogeneity and improve management.

Indexed as

Bacterial loadBandim TB scoreDisease severityGeneXpertHost–pathogen interactionTuberculosis

Identifiers

PMID42565036
PMCPMC13446365

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.