ArticleFrontiers in immunology2026
Dysregulated expression of PSGL-1 and ADAM8 in Sjögren's disease: potential contribution to disease pathogenesis.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Sjögren's disease (SjD) is a systemic autoimmune disease showing clinical characteristics similar to systemic lupus erythematosus (SLE) and systemic sclerosis (SSc) at early phases, complicating diagnosis. Methods: In this cross-sectional study, blood was obtained from 65 SjD, 34 SLE, and 44 SSc patients and 56 healthy donors (HD). Numbers and percentage of circulating leukocytes and expression of HLA-DR, PSGL-1, ADAM8, IL-10 and IFNα were determined by flow cytometry. Results: Compared to HD, SjD patients showed generalized immune system activation and global reduction of circulating leukocytes, except for plasma cells, which were increased. IFNα levels were reduced in SjD CD16- monocytes, dendritic cells (DC), B cells and basophils, but increased in SjD CD16 Conclusions: Dysregulated PSGL-1 and ADAM8 expression in SjD circulating cells is associated with important clinical manifestations in SjD patients, supporting their potential relevance as therapeutic targets in this disease. Additionally, we found PS1B and PPr as new cellular biomarkers that could help improve SjD diagnostic accuracy, particularly in seronegative or ambiguous cases during the early phase of disease.
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