ArticleFrontiers in neuroscience2026
Intraocular pressure spikes after intravitreal injection and their impact on OCT angiography.
Article in Frontiers in neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To evaluate whether acute intraocular pressure (IOP) elevation after intravitreal anti-VEGF injection affects superficial capillary plexus (SCP) perfusion metrics on optical coherence tomography angiography (OCTA). Methods: In this prospective single-center study, adults scheduled for unilateral intravitreal anti-VEGF treatment for macular edema were enrolled. Assessments were performed pre-injection (T1), early post-injection (T2), and 10 min after T2 (T3). OCTA (CIRRUS HD-OCT 5000; AngioPlex Metrix v11.0) used 6 × 6 mm fovea-centered scans. SCP vessel density (VD) and perfusion density (PD) were quantified for central (1 mm), inner (3 mm), and full macular fields (ETDRS grid). IOP was measured at T1-T3. Scans with signal strength index (SSI) < 6 or relevant motion/segmentation artefacts were excluded. Spearman correlation and multivariable regression analysis assessed associations of VD/PD with IOP and SSI. Results: Of 81 recruited subjects, 54 eyes (66.7%) finally met OCTA quality criteria at all timepoints and were analyzed. Mean IOP increased from 13.98 ± 3.09 mmHg (T1) to 31.15 ± 9.65 mmHg (T2; Conclusion: Intravitreal anti-VEGF injection caused a marked acute IOP spike, but most SCP OCTA metrics did not change at T2. The decline in SCP metrics at T3 coincided with reduced SSI and correlated more strongly with image quality than with IOP, indicating that post-procedural OCTA image quality may influence measured perfusion metrics; however, in the absence of blood pressure measurements, a physiological contribution cannot be excluded.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.