Evidence map›Paper›PMID 42564971›Full record

ArticleEnvironmental health perspectives2026

Exposures to Drinking Water Contaminants in Community Water Systems and Risk of Ovarian Cancer in the California Teachers Study Cohort.

Maya Spaur, Lauren M Hurwitz, Danielle N Medgyesi, Alexander P Keil, Laura E Beane Freeman, Jared A Fisher, Jessica M Madrigal, Samantha Ammons, Emma S Spielfogel, Komal Bangia and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental health perspectives, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Maya SpaurOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20892, United States.
Lauren M HurwitzOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20892, United States.
Danielle N MedgyesiDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, United States.
Alexander P KeilOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20892, United States.
Laura E Beane FreemanOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20892, United States.
Jared A FisherOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20892, United States.ORCID 0000-0001-9203-5742
Jessica M MadrigalOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20892, United States.
Samantha AmmonsOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20892, United States.
Emma S SpielfogelDivision of Health Analytics, Department of Computational and Quantitative Medicine, Beckman Research Institute City of Hope, Duarte, California 91010, United States.
Komal BangiaCommunity and Environmental Epidemiology Research Branch, Office of Environmental Health Hazard Assessment, Oakland, California 94612, United States.
Paul S AlbertBiostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20850, United States.
Tiffany R SanchezDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, United States.
James V LaceyDivision of Health Analytics, Department of Computational and Quantitative Medicine, Beckman Research Institute City of Hope, Duarte, California 91010, United States.
Rena R JonesOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20892, United States.ORCID 0000-0003-1294-1679
Mary H WardOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20892, United States.

Funding

VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DIANE M SIMEONE · 1985 to 2026
$124.9M
Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI John Charles Williams · 1985 to 2026
$86.3M
CALIFORNIA TEACHERS STUDYR01CA077398 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BERNSTEIN, LESLIE · 1998 to 2014
$29.7M
Oil and Gas as Drivers of Climate Change and Health: Developing unique resources to investigate multi-level and diverse effects of exposure to oil and gas wellsU01CA199277 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI LACEY, JAMES V, MARTINEZ, MARIA ELENA · 2015 to 2024
$20.7M
New Biospecimens to Enhance Research in the California Teachers Study CohortUM1CA164917 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI LACEY, JAMES V · 2012 to 2015
$10.1M
INVESTIGATIONS OF ENVIRONMENTAL EXPOSURES AND CANCERZ01CP010125 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI CANTOR, KENNETH · 1996 to 2008
$108k
Intramural NIH HHS Z01 CP010125NCI NIH HHS P30 CA023100NCI NIH HHS P30 CA033572NCI NIH HHS R01 CA077398NCI NIH HHS U01 CA199277NCI NIH HHS UM1 CA164917
6 · The paper itself

Abstract

backgroundSeveral drinking water contaminants are known or suspected carcinogens; however, there are only a few investigations of drinking water exposure and ovarian cancer. We evaluated associations between regulated contaminants in community water systems (CWS) and ovarian cancer risk in the California Teachers Study, a prospective cohort of female California educators.

methodsParticipants were cancer-free, without bilateral oophorectomy, living in California at baseline (1995-1996) with geocoded addresses linked to a CWS (

resultsAlmost all women (>99%) had average exposures below regulatory limits for all contaminants. In single contaminant analyses, a doubling in average uranium concentrations was associated with all ovarian cancer (HR

conclusionsNovel associations between drinking water contaminants and ovarian cancer risk at levels below regulatory limits warrant further investigation.

Indexed as

Drinking WaterEnvironmental ExposureOvarian NeoplasmsWater Pollutants, ChemicalAdultArsenicCaliforniaCohort StudiesFemaleHumansNitratesProspective StudiesArsenicDrinking WaterNitratesWater Pollutants, Chemical

Identifiers

PMID42564971
PMCPMC13445266

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.