Evidence map›Paper›PMID 42564929›Full record

ArticlePeerJ2026

Spatial heterogeneity of rumen development in lambs: morphological characteristics, growth associations, and transcriptomic insights.

Jiale Jia, Yunfei Xu, Guoxiu Wang, Weimin Wang, Kaidong Li, Anfeng Zhu, Jing Zhao, Yang Zhang, Zhen Liu, Zichun Miao and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jiale JiaCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou, Gansu, China.
Yunfei XuCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou, Gansu, China.
Guoxiu WangCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou, Gansu, China.
Weimin WangThe State Key Laboratory of Grassland Agro-Ecosystems, College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, Gansu, China.
Kaidong LiTongze Agriculture Co, Minqin, Gansu, China.
Anfeng ZhuCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou, Gansu, China.
Jing ZhaoCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou, Gansu, China.
Yang ZhangCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou, Gansu, China.
Zhen LiuCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou, Gansu, China.
Zichun MiaoCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou, Gansu, China.
Chong LiCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou, Gansu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rumen development shows clear spatial specificity, with distinct tissue morphology and proliferation patterns across regions. This heterogeneity likely results from region-specific transcriptional regulation. Identifying key genes and signaling pathways underlying these spatial differences is helpful for understanding the molecular basis of rumen development. This study investigated the morphological characteristics of different rumen regions in lambs, analyzed their associations with growth performance and fermentation parameters, and explored the underlying transcriptomic profiles. Histological observations revealed pronounced regional variation in rumen morphology. The ventral sac exhibited longer and denser papillae and a thicker keratinized layer than the blind sacs. Correlation analysis showed that papilla length and density were positively associated with growth performance traits such as body weight and average daily gain. Transcriptomic analysis revealed the highest number of differentially expressed genes (DEGs) between the ventral and caudoventral blind sacs. Functional enrichment indicated that DEGs were enriched in focal adhesion,

Indexed as

RumenTranscriptomeAnimalsGene Expression ProfilingSheepSignal TransductionKeratinizationRumen developmentSpatial specificityTranscriptome

Identifiers

PMID42564929
PMCPMC13446227

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.