Evidence map›Paper›PMID 42564927›Full record

ArticleArthroplasty today2026

Perioperative Dexamethasone Is Associated With a Reduced Risk of Periprosthetic Joint Infection Following Aseptic Revision Total Hip and Knee Arthroplasty.

Sahil S Telang, Pranit Kumaran, Sagar Telang, Ian A Jones, Julian Wier, Andrew G Yun, Jay R Lieberman, Nathanael D Heckmann

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arthroplasty today, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sahil S TelangDepartment of Orthopaedic Surgery, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.
Pranit KumaranDepartment of Orthopaedic Surgery, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.
Sagar TelangDepartment of Orthopaedic Surgery, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.
Ian A JonesDepartment of Orthopaedic Surgery, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.
Julian WierDepartment of Orthopaedic Surgery, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.
Andrew G YunDepartment of Orthopaedic Surgery, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.
Jay R LiebermanDepartment of Orthopaedic Surgery, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.
Nathanael D HeckmannDepartment of Orthopaedic Surgery, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Dexamethasone has been increasingly used perioperatively for arthroplasty procedures. However, there is limited evidence on its use and safety for revision total hip (THA) and knee arthroplasty (TKA). This study sought to assess the association between perioperative dexamethasone administration and postoperative infectious complications in patients undergoing aseptic revision THA and TKA. Methods: Using a national healthcare database, we identified adult patients undergoing aseptic, both-component revision THA and TKA between 2016 and 2023. Patients were stratified into those treated by high- (DEX[+]) or low-use (DEX[-]) dexamethasone surgeons using k-means clustering. Mixed-effects logistic regression was used to compare the 90-day rates of periprosthetic joint infection (PJI) and composite infectious outcomes between the DEX(+) and DEX(-) cohorts. Results: In total, 35,222 patients were identified who underwent aseptic revision THA (n = 12,771) and TKA (n = 22,451). When accounting for surgeon clustering and comorbidities, DEX(+) demonstrated lower odds of PJI in revision THA (1.05% vs 3.42%, adjusted odds ratio [aOR]: 0.72, 95% confidence interval [CI]: 0.53-0.978, Conclusions: Perioperative dexamethasone use was associated with reduced PJI and infectious risk following aseptic revision THA and TKA, supporting the routine dexamethasone administration in revision arthroplasty procedures.

Indexed as

DexamethasoneHipInfectionKneePeriprosthetic joint infectionRevision arthroplasty

Identifiers

PMID42564927
PMCPMC13445502

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.