ArticleFrontiers in microbiology2026
Adaptive laboratory evolution of
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Extensive research on model microorganisms under kosmotropic sodium chloride stress has established much of what is known about the genetic and molecular mechanisms of osmoregulation. However, genetic adaptation to chaotropic salts such as magnesium chloride remains poorly defined. Chaotropes destabilize biomolecules and can constrain biomanufacturing, underscoring the need to enhance stress tolerance to improve production efficiency. Environmentally, the exceptional chaotropic activity of magnesium chloride brines offers rare opportunities to probe the limits of life, with major implications for bioprospecting and astrobiology. To explore mechanisms of adaptation to high chaotropicity, we used adaptive laboratory evolution (ALE) to isolate
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