Evidence map›Paper›PMID 42564844›Full record

ArticleCase reports in ophthalmological medicine2026

When the Eye Reveals Disseminated Tuberculosis: A Pediatric Case of Endophthalmitis With Severe CNS Involvement.

Nicola De Santi, Laura Curci, Eduardo Bianchi, Barbara Iaccheri, Carlo Pallotto, Daniele Rosignoli, Tito Fiore, Giuseppe Vittorio Luigi De Socio, Carlo Cagini

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Case reports in ophthalmological medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nicola De SantiDepartment of Medicine Surgical, Section of Ophthalmology, University of Perugia, S. Maria della Misericordia Hospital, Perugia, Italy, unipg.it.ORCID https://orcid.org/0009-0008-5047-4745
Laura CurciInfectious Diseases Clinic, Santa Maria Della Misericordia Hospital, Department of Medicine, University of Perugia, Perugia, Italy, unipg.it.
Eduardo BianchiDepartment of Medicine Surgical, Section of Ophthalmology, University of Perugia, S. Maria della Misericordia Hospital, Perugia, Italy, unipg.it.ORCID https://orcid.org/0009-0005-3423-1071
Barbara IaccheriDepartment of Medicine Surgical, Section of Ophthalmology, University of Perugia, S. Maria della Misericordia Hospital, Perugia, Italy, unipg.it.ORCID https://orcid.org/0000-0003-1648-0849
Carlo PallottoInfectious Diseases Clinic, Santa Maria Della Misericordia Hospital, Department of Medicine, University of Perugia, Perugia, Italy, unipg.it.ORCID https://orcid.org/0000-0002-0355-2885
Daniele RosignoliInfectious Diseases Clinic, Santa Maria Della Misericordia Hospital, Department of Medicine, University of Perugia, Perugia, Italy, unipg.it.
Tito FioreDepartment of Medicine Surgical, Section of Ophthalmology, University of Perugia, S. Maria della Misericordia Hospital, Perugia, Italy, unipg.it.ORCID https://orcid.org/0000-0003-2410-9775
Giuseppe Vittorio Luigi De SocioInfectious Diseases Clinic, Santa Maria Della Misericordia Hospital, Department of Medicine, University of Perugia, Perugia, Italy, unipg.it.ORCID https://orcid.org/0000-0001-8774-4843
Carlo CaginiDepartment of Medicine Surgical, Section of Ophthalmology, University of Perugia, S. Maria della Misericordia Hospital, Perugia, Italy, unipg.it.ORCID https://orcid.org/0000-0002-3812-9219

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: This study aims to report a case of tuberculosis involving central nervous system (CNS) discovered thanks to tubercular endophathlmitis. Methods: This is a case report. Observation: A 14-year-old male presented with acute visual loss, ocular pain, and redness of the right eye following a recent stay in India. The clinical history was notable for prolonged fever, night sweats, and headache. Ophthalmological examination revealed severe intraocular inflammation consistent with panuveitis and endophthalmitis. Neuroimaging demonstrated a large ring-enhancing lesion in the right hemisphere with significant mass effect. Initial microbiological investigations, including vitreous sampling, were negative. A positive interferon-gamma release assay and radiological findings raised suspicion for disseminated tuberculosis, and Conclusion: This case highlights the diagnostic complexity of ocular and CNS tuberculosis and emphasizes the need for a high index of suspicion, repeated targeted sampling, and multidisciplinary management to achieve timely diagnosis and appropriate treatment.

Indexed as

central nervous system tuberculosiscerebral tuberculomaextrapulmonary tuberculosisocular tuberculosispanuveitispediatric tuberculosistuberculosistuberculous endophthalmitis

Identifiers

PMID42564844
PMCPMC13445253

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.