Evidence map›Paper›PMID 42564842›Full record

ArticleInternational journal of dentistry2026

Association of Pulp Stones With Single Nucleotide Polymorphisms of Mineralization-Related Genes in Orthodontically Treated Patients: A Cross-Sectional Study.

Daniel Hemming, Bianca Marques de Mattos de Araujo, Christian Kirschneck, Rafaela Scariot, Camila Paiva Perin, Manoel D Sousa-Neto, Gabriela Fonseca-Souza, Natanael Henrique Ribeiro Mattos, Michelle Nascimento Meger, Flares Baratto-Filho and 1 more

Abstract read
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In one paragraph

Article in International journal of dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Daniel HemmingSchool of Dentistry, Tuiuti University of Paraná, Curitiba, Paraná, Brazil, utp.edu.br.ORCID https://orcid.org/0009-0005-3141-8906
Bianca Marques de Mattos de AraujoSchool of Dentistry, Tuiuti University of Paraná, Curitiba, Paraná, Brazil, utp.edu.br.ORCID https://orcid.org/0000-0002-7507-4667
Christian KirschneckDepartment of Orthodontics, Medical Faculty, University Hospital Bonn, Bonn, Germany, uni-bonn.de.ORCID https://orcid.org/0000-0001-9473-8724
Rafaela ScariotDepartment of Stomatology, Federal University of Parana, Curitiba, Paraná, Brazil, ufpr.br.ORCID https://orcid.org/0000-0002-4911-6413
Camila Paiva PerinSchool of Dentistry, Tuiuti University of Paraná, Curitiba, Paraná, Brazil, utp.edu.br.ORCID https://orcid.org/0000-0002-4646-8851
Manoel D Sousa-NetoDepartment of Restorative Dentistry, University of São Paulo, Ribeirão Preto, São Paulo, Brazil, usp.br.ORCID https://orcid.org/0000-0002-7696-7600
Gabriela Fonseca-SouzaSchool of Dentistry, Tuiuti University of Paraná, Curitiba, Paraná, Brazil, utp.edu.br.ORCID https://orcid.org/0000-0002-8040-8553
Natanael Henrique Ribeiro MattosSchool of Dentistry, Tuiuti University of Paraná, Curitiba, Paraná, Brazil, utp.edu.br.ORCID https://orcid.org/0000-0003-2755-2270
Michelle Nascimento MegerSchool of Dentistry, Tuiuti University of Paraná, Curitiba, Paraná, Brazil, utp.edu.br.ORCID https://orcid.org/0000-0002-1776-2373
Flares Baratto-FilhoSchool of Dentistry, Tuiuti University of Paraná, Curitiba, Paraná, Brazil, utp.edu.br.ORCID https://orcid.org/0000-0002-5649-7234
Erika Calvano KüchlerDepartment of Orthodontics, Medical Faculty, University Hospital Bonn, Bonn, Germany, uni-bonn.de.ORCID https://orcid.org/0000-0001-5351-2526

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: The current evidence suggests that the formation of pulp stones (PS) has a genetic background. Therefore, the present study aimed to evaluate the association between PS in orthodontically treated patients and single nucleotide polymorphisms (SNPs) in the mineralization-related genes ( Materials and Methods: This cross-sectional study analyzed genomic DNA and panoramic radiographs from patients with a history of orthodontic treatment. Panoramic radiographs were analyzed and PS were identified as well- or poorly defined radiopaque opacities located within the pulp chamber of the maxillary and mandibular first and second permanent molars. Genomic DNA obtained from all participants was analyzed. The genetic analysis focused on seven specific SNPs located in genes involved in mineralization pathways: Results: The final sample comprised 235 patients: 120 presented with PS, and 115 served as controls. For the SNP rs59983488 in Conclusion: Our study suggests that RUNX2 could have a small effect on the susceptibility of orthodontic patients to develop PS.

Identifiers

PMID42564842
PMCPMC13446016

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