Evidence map›Paper›PMID 42564818›Full record

ArticleResearch and practice in thrombosis and haemostasis2026

Cancer-associated stroke: a comparative analysis of thrombus composition, resistance to lysis, and plasma biomarkers.

Capucine Habay, Benoît Ho-Tin-Noé, Mialitiana Solo Nomenjanahary, Véronique Ollivier, Ilham Arab, Lina-Rose Kabbaj, Mikaël Mazighi, Nadine Ajzenberg, Jean-Philippe Desilles, Dorothée Faille and 1 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Research and practice in thrombosis and haemostasis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Capucine HabayUniversité Paris Cité, Inserm, UMRS-1144, Optimisation Thérapeutique en Neuropsychopharmacologie, Paris, France.
Benoît Ho-Tin-NoéUniversité Paris Cité, Inserm, UMRS-1144, Optimisation Thérapeutique en Neuropsychopharmacologie, Paris, France.
Mialitiana Solo NomenjanaharyUniversité Paris Cité, Inserm, UMRS-1144, Optimisation Thérapeutique en Neuropsychopharmacologie, Paris, France.
Véronique OllivierUniversité Paris Cité, Inserm, UMRS-1144, Optimisation Thérapeutique en Neuropsychopharmacologie, Paris, France.
Ilham ArabUniversité Paris Cité, Inserm, UMRS-1144, Optimisation Thérapeutique en Neuropsychopharmacologie, Paris, France.
Lina-Rose KabbajUniversité Paris Cité, Inserm, UMRS-1144, Optimisation Thérapeutique en Neuropsychopharmacologie, Paris, France.
Mikaël MazighiUniversité Paris Cité, Inserm, UMRS-1144, Optimisation Thérapeutique en Neuropsychopharmacologie, Paris, France.
Nadine AjzenbergUniversité Paris Cité, Inserm, UMRS-1144, Optimisation Thérapeutique en Neuropsychopharmacologie, Paris, France.
Jean-Philippe DesillesUniversité Paris Cité, Inserm, UMRS-1144, Optimisation Thérapeutique en Neuropsychopharmacologie, Paris, France.
Dorothée FailleUniversité Paris Cité, Inserm, UMRS-1144, Optimisation Thérapeutique en Neuropsychopharmacologie, Paris, France.
compoCLOT study group∗

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Acute ischemic stroke (AIS) is a significant complication of cancer and may reveal occult malignancy. Whether cancer-related AIS (CAS) provides specific biological features remains unclear. Objectives: This case-control study aimed to characterize thrombi and plasmas from patients with CAS. Methods: Nine consecutive patients with CAS, including 3 nonbacterial thrombotic endocarditis (NBTE), and age- and sex-matched AIS controls with cardioembolism (CE, Results: CAS thrombi were resistant to tissue-type plasminogen activator lysis compared with LAA thrombi (median thrombus weight conservation, 92% vs 9%; Conclusions: CAS thrombi exhibit distinct properties, with white thrombi as a hallmark of undiagnosed NBTE. Furthermore, plasma biomarkers such as D-dimer, fibrin monomers, extracellular vesicle-associated tissue factor and myeloperoxidase could help in cancer screening in AIS of unknown etiology.

Indexed as

Ischemic StrokeNeoplasmsStrokeThrombosisAgedAged, 80 and overBiomarkersCase-Control StudiesFemaleFibrinolytic AgentsHumansMaleMiddle AgedPeroxidasePlatelet Factor 4ThrombectomyBiomarkersFibrinolytic AgentsMPO protein, humanPeroxidasePlatelet Factor 4Tissue Plasminogen Activatorvon Willebrand Factorbiomarkerscancerstrokethrombusvon Willebrand Factor

Identifiers

PMID42564818
PMCPMC13444497

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.