Evidence map›Paper›PMID 42564789›Full record

ArticleiScience2026

Multifunctional LA and PTMC coating for biliary stents to combat cholangiocarcinoma proliferation in obstruction.

Liang Jin, Yaoting Wang, Yaohui Liu, Qianping Mao, Ben Feng, Jiaxing Xin, Yumei Zhang, Lan Li, Xiaodan Guan, Xiaolong Wu and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Liang JinSchool of Medical Technology and Information Engineering & School of Life Science & School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Yaoting WangSchool of Medical Technology and Information Engineering & School of Life Science & School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Yaohui LiuRWTH Aachen University, 52062 Aachen, Germany.
Qianping MaoSchool of Medical Technology and Information Engineering & School of Life Science & School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Ben FengShanghai Key Laboratory of Compound Chinese Medicines, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Jiaxing XinSchool of Medical Technology and Information Engineering & School of Life Science & School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Yumei ZhangShanghai East Hospital Affiliated to Tongji University, Shanghai 200120, China.
Lan LiSchool of Medical Technology and Information Engineering & School of Life Science & School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Xiaodan GuanSchool of Medical Technology and Information Engineering & School of Life Science & School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Xiaolong WuSchool of Medical Technology and Information Engineering & School of Life Science & School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Zhengtao WangShanghai Key Laboratory of Compound Chinese Medicines, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Li YuSchool of Medical Technology and Information Engineering & School of Life Science & School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Ling ZhangSchool of Medical Technology and Information Engineering & School of Life Science & School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Rui ZanYiwu Research Institute of Fudan University, Yi Wu 322099, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Licorice-derived licochalcone A (LA) has antitumor effects, while conventional PTMC-coated biliary stents relieve malignant biliary obstruction but lack tumor-suppressive function and suffer from in-stent restenosis. This study fabricated an LA-loaded PTMC composite stent coating via favorable material compatibility for local sustained drug delivery. The coating improves surface hydrophobicity, enables stable LA release and good biocompatibility, and efficiently inhibits cholangiocarcinoma and colorectal cancer cell growth and tumor progression. LA exerts antitumor activity by regulating the CYP19A1-mediated GPR30-AKT pathway. This dual-functional coating offers a feasible strategy for clinical biliary stent modification and local tumor intervention.

Indexed as

antifoulingcholangiocarcinomaCYP19A1-GPR30-AKTLA@PTMC coatingtumor proliferation

Identifiers

PMID42564789
PMCPMC13444472

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.