ArticleThe South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa2026
Investigation of serum lactate dehydrogenase levels in generalised anxiety disorder.
Article in The South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Lactate dehydrogenase (LDH) plays a crucial role in glucose metabolism by catalysing the conversion of pyruvate to lactate and facilitating lactate utilisation. Given LDH's central role in energy metabolism, it may serve as a promising biomarker for anxiety disorders. Aim: This study aimed to compare serum LDH levels between patients with generalised anxiety disorder (GAD) and healthy controls (HC) and to examine the associations between LDH levels and clinical features. Setting: Bursa City Hospital: A tertiary hospital in Bursa, Turkey. Methods: This study included 113 participants with GAD and 90 HC. Group comparisons were conducted using an independent samples Results: Serum LDH levels were significantly lower in the GAD compared to the HC (157.7 ± 18.7 vs. 173.2 ± 23.3; Conclusion: These findings support the hypothesis that LDH may represent a potential biomarker and therapeutic target in the clinical management of anxiety. Contribution: This study is the first to report significantly reduced LDH levels in individuals with GAD, highlighting a potential link between altered lactate metabolism and anxiety pathogenesis.
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