Evidence map›Paper›PMID 42564764›Full record

ArticleMaterials today. Bio2026

An infection-responsive multifunctional hydrogel enables potent activity against methicillin-resistant

Chuanliang Fu, Wenjing Zhang, Renyuan Wang, Runyi Cao, Zhengjie Chen, Peilin Wang, Ying Peng, Yilin Huo, Yi Hu, Zun Ren and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Chuanliang FuTrauma Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China.
Wenjing ZhangTrauma Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China.
Renyuan WangPrecision Research Center for Refractory Diseases, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China.
Runyi CaoPrecision Research Center for Refractory Diseases, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China.
Zhengjie ChenKey Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Peilin WangTrauma Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China.
Ying PengTrauma Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China.
Yilin HuoTrauma Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China.
Yi HuTrauma Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China.
Zun RenTrauma Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China.
Hao ZhangTrauma Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China.
Yersen MulatTrauma Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China.
Zhengjie LuoKey Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Yahui DaiTrauma Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China.
Min ZhouKey Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Haodong LinTrauma Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infected wounds remain a significant clinical challenge due to bacterial resistance and impaired healing. Therefore, developing effective antibacterial agents and precise delivery systems is crucial for rapid wound repair. To address this, we constructed zeolitic imidazolate framework-8 (ZIF-8) nanoparticles loaded with the host defense peptide-mimicking glycine-poly(2-oxazoline) (Gly-POX) and incorporated them into methacrylated gelatin (GelMA) to prepare the Gel-P@Z nanocomposite hydrogel. The hydrogel integrates the following core design elements: the pH-responsive degradation of ZIF-8 enables targeted drug release within the infected microenvironment; Gly-POX, mimicking the structure of host defense peptides, exerts membrane-disruptive antibacterial activity against MRSA, which possesses a negatively charged cell membrane, through its positively charged side chains; and the GelMA hydrogel provides a three-dimensional extracellular matrix-like scaffold that supports cell adhesion and proliferation. Gel-P@Z exhibited a slow and sustained release of Gly-POX and achieved >99% antibacterial efficacy against drug-resistant bacteria without toxicity. Moreover, Gel-P@Z promoted macrophage polarization from M1 to M2 phenotype and enhanced efferocytosis, while also facilitating fibroblast migration and inducing contraction in

Indexed as

Host defense peptideMRSAPoly(2-oxazoline)Wound healingZIF-8

Identifiers

PMID42564764
PMCPMC13445519

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.