ArticleNew microbes and new infections2026
Molecular and serological characterization of SARS-CoV-2 strains associated with viral encephalitis in Senegal during the COVID-19 pandemic.
Article in New microbes and new infections, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Beyond its socio-economic impact, COVID-19 has been associated with respiratory, gastrointestinal, neurological and neuropsychiatric symptoms across many countries, including in Senegal. While the SARS-CoV-2 virus primarily targets the respiratory and cardiovascular systems, if not detected and treated early, it can invade the nervous system and lead to severe neurological complications. This study focuses on the molecular and serological characterization of the SARS-CoV-2 strains associated with encephalitis manifestations of the disease. The presence of the virus in the central nervous system was confirmed by RT-PCR and sequencing and also serological techniques. Genetic analysis identified Delta (B.1.617.2-like) and Eta (B.1.525-like) variants in encephalitis patients. In silico analysis revealed three mutations (p.Pro4619Leu, p.Ala103Pro and p.Thr40Ile) predicted to affect protein function, generating hypotheses regarding their possible involvement in neurological manifestations. Among 11 patients with SARS-CoV-2-associated encephalitis, 30% had SARS-CoV-2 IgG antibodies in their serum, and 20% had them in cerebrospinal fluid (CSF). As part of the surveillance system for infectious encephalitis in Senegal (ENSENE), our data provided evidence of SARS-CoV-2 involvement in the epidemiology of viral encephalitis during the COVID-19 pandemic. Similar approaches should be promoted in future studies to investigate the biological significance of these mutations and improve the diagnosis and management of neurological manifestations associated with SARS-CoV-2 infection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.