ArticleInternational journal of genomics2026
Multiomics Integration Reveals Coexpression Regulatory Networks in Osteoporosis and Osteosarcoma.
Article in International journal of genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Multiomics Integration Reveals Coexpression Regulatory Networks in Osteoporosis and Osteosarcoma.International journal of genomics · 2026Article
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3 authors.
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Abstract
Background: Osteoporosis and osteosarcoma impose a substantial and rising global health burden, yet their transcriptomic landscapes have not been systematically compared. We performed a multiomics characterization integrating bulk transcriptomics, coexpression network analysis, immune deconvolution, single-cell RNA sequencing, and diagnostic classifier construction. Methods: Bulk transcriptomic profiling was performed using GSE56815 (circulating blood monocytes, Results: Differential expression analysis identified 4347 probe sets at nominal Conclusions: This integrative multiomics study provides a comprehensive transcriptomic comparison of osteoporosis and osteosarcoma, identifies BMD-associated coexpression modules with experimentally validated hub genes, and establishes a reusable analytical framework for biomarker discovery in metabolic and malignant bone disease. However, the weak module-trait correlations, subthreshold classifier performance in some cross-validation folds, and the use of circulating blood monocytes to study bone-specific gene expression warrant cautious interpretation of the findings.
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