Evidence map›Paper›PMID 42564709›Full record

ArticleJournal of clinical & translational endocrinology2026

Impact of gender-affirming hormone therapy on dry eye.

Keith E Arnold, Michael J Foster, Tomasz A Tabernacki, Chase A Turner, Peter A Netland, Kirtishri Mishra

Abstract read
In one paragraph

Article in Journal of clinical & translational endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Keith E ArnoldCase Western Reserve University School of Medicine, Cleveland, OH, USA.
Michael J FosterCase Western Reserve University School of Medicine, Cleveland, OH, USA.
Tomasz A TabernackiCase Western Reserve University School of Medicine, Cleveland, OH, USA.
Chase A TurnerCase Western Reserve University School of Medicine, Cleveland, OH, USA.
Peter A NetlandDepartment of Ophthalmology, Eastern Virginia Medical School at Old Dominion University, Norfolk, Virginia, USA.
Kirtishri MishraCase Western Reserve University School of Medicine, Cleveland, OH, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To determine whether gender-affirming hormone therapy (GAHT) influences tear system health in transgender individuals. Methods: This retrospective cohort observational study analyzed data from transgender men and women ages ≥18-years between 2004 and 2024 via electronic medical record (EMR) data. Following propensity score matching, subjects on hormone therapy included 23,623 transgender men, 15,933 transgender women, and an equal number in each matched control group. Results: Among transgender men and women, respectively, tear system disorders occurred in 0.90% and 0.94% of those using GAHT and 0.90% and 1.17% of those not using GAHT ( Conclusions: In this cohort, EMR-documented masculinizing or feminizing GAHT was not associated with an increased incidence of recorded tear-system disorders.

Indexed as

dry eyekeratoconjunctivitis siccalacrimal system disordersmeibomian gland dysfunctiontear filmtransgender adults

Identifiers

PMID42564709
PMCPMC13445475

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.