ArticleJAC-antimicrobial resistance2026
Carbapenemase type-dependent pharmacodynamic activity of minocycline-biapenem combination against carbapenemase-producing
Article in JAC-antimicrobial resistance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: The activity of antimicrobial combinations against carbapenemase-producing Methods: A total of 79 clinical CPKP isolates from Japan ( Results: Single-agent MIC90 values of minocycline were 32, 16, 8, 32 and 32 mg/L for NDM, IMP, KPC, OXA-48-like and NDM+OXA-48-like isolates, respectively; corresponding biapenem MIC90 values were 32, 2, 256, 8 and 256 mg/L. Synergistic interactions (FICI ≤0.5) with the minocycline-biapenem combination were observed against 98% of NDM, 80% of IMP, 60% of KPC, 38% of OXA-48-like and 100% of NDM+OXA-48-like isolates. At minocycline 4 mg/L plus biapenem 1 mg/L, inhibition rates were 98%, 100%, 80% and 63% for NDM, IMP, KPC and OXA-48-like isolates, respectively. Conclusions: The activity of the minocycline-biapenem combination differs substantially according to carbapenemase type. These findings indicate that combination efficacy is not predictable from single-agent susceptibility alone and highlight the importance of pharmacodynamic evaluation when optimizing treatment strategies for CPKP.
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